| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258867 |
|
|
Cricetulus griseus |
|
| pmid |
sentence |
| 9760039 |
A range of serotonergic agonists and partial agonists were tested for their capacity to stimulate 5-HT1A receptor mediated GTPg binding in CHO-h5-HT1A membranes. The methoxynaphtylpiperazine ligand, S 14671,was the most potent agonist tested, with virtually full agonist activity, relative to 5-HT Table 1; Fig. 2C consistent with its exceptionally potent and efficacious actions in in vivo functional paradigms. Its analogue, S 14506 was also a highly potent and efficacious ligand (Emax90%) in agreement with previous in vivo studies ( Schreiber et al., 1994 ). (+)UH 301 exhibited partial agonist activity at 5-HT1A receptors |
|
3.0
(R)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin
chemical activation