| + |
BDH2 | up-regulates quantity 
chemical modification
|
acetoacetate |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282518 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16380372 |
Human DHRS6 is a previously uncharacterized member of the short chain dehydrogenases/reductase family and displays significant homologies to bacterial hydroxybutyrate dehydrogenases. Substrate screening reveals sole NAD+-dependent conversion of (R)-hydroxybutyrate to acetoacetate with Km values of about 10 mm, consistent with plasma levels of circulating ketone bodies in situations of starvation or ketoacidosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(R)-3-hydroxybutyrate | up-regulates quantity
precursor of
|
acetoacetate |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282519 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16380372 |
Human DHRS6 is a previously uncharacterized member of the short chain dehydrogenases/reductase family and displays significant homologies to bacterial hydroxybutyrate dehydrogenases. Substrate screening reveals sole NAD+-dependent conversion of (R)-hydroxybutyrate to acetoacetate with Km values of about 10 mm, consistent with plasma levels of circulating ketone bodies in situations of starvation or ketoacidosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AACS | down-regulates quantity 
chemical modification
|
acetoacetate |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282521 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 37356666 |
Acetoacetyl-CoA synthetase (AACS) is the key enzyme in the anabolic utilization of ketone bodies (KBs) for denovo lipid synthesis, a process that bypasses citrate and ATP citrate lyase. Acetoacetyl-CoA (AcAc-CoA) synthetase (AACS) (AcAc-CoA ligase, Enzyme Commission no.: 6.2.1.16) is a cytosolic lipogenic enzyme found in many tissues involved in lipid synthesis (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11). It catalyzes the coupling of acetoacetate (AcAc), one of the ketone bodies (KBs), to CoA in the reaction shown below to produce cytosolic AcAc-CoA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
acetoacetate | up-regulates quantity
precursor of
|
acetoacetyl-CoA(4-) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282527 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 37356666 |
Acetoacetyl-CoA synthetase (AACS) is the key enzyme in the anabolic utilization of ketone bodies (KBs) for denovo lipid synthesis, a process that bypasses citrate and ATP citrate lyase. Acetoacetyl-CoA (AcAc-CoA) synthetase (AACS) (AcAc-CoA ligase, Enzyme Commission no.: 6.2.1.16) is a cytosolic lipogenic enzyme found in many tissues involved in lipid synthesis (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11). It catalyzes the coupling of acetoacetate (AcAc), one of the ketone bodies (KBs), to CoA in the reaction shown below to produce cytosolic AcAc-CoA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGCLL1 | up-regulates quantity
chemical modification
|
acetoacetate |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282529 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31817290 |
There are three human enzymes with HMG-CoA lyase activity that are able to synthesize ketone bodies in different subcellular compartments. The mitochondrial HMG-CoA lyase was the first to be described, and catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetate and acetyl-CoA, the common final step in ketogenesis and leucine catabolism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) | up-regulates quantity
chemical modification
|
acetoacetate |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282531 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31817290 |
There are three human enzymes with HMG-CoA lyase activity that are able to synthesize ketone bodies in different subcellular compartments. The mitochondrial HMG-CoA lyase was the first to be described, and catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetate and acetyl-CoA, the common final step in ketogenesis and leucine catabolism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
acetoacetate