| + |
HMGCLL1 | down-regulates quantity 
chemical modification
|
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282528 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31817290 |
There are three human enzymes with HMG-CoA lyase activity that are able to synthesize ketone bodies in different subcellular compartments. The mitochondrial HMG-CoA lyase was the first to be described, and catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetate and acetyl-CoA, the common final step in ketogenesis and leucine catabolism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) | up-regulates quantity 
chemical modification
|
acetoacetate |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282531 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31817290 |
There are three human enzymes with HMG-CoA lyase activity that are able to synthesize ketone bodies in different subcellular compartments. The mitochondrial HMG-CoA lyase was the first to be described, and catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetate and acetyl-CoA, the common final step in ketogenesis and leucine catabolism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) | up-regulates quantity
chemical modification
|
acetyl-CoA(4-) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282532 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31817290 |
There are three human enzymes with HMG-CoA lyase activity that are able to synthesize ketone bodies in different subcellular compartments. The mitochondrial HMG-CoA lyase was the first to be described, and catalyzes the cleavage of 3-hydroxy-3-methylglutaryl CoA to acetoacetate and acetyl-CoA, the common final step in ketogenesis and leucine catabolism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)