| + |
LEPR | down-regulates quantity 
|
AGRP |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253076 |
|
|
|
|
| pmid |
sentence |
| 27154742 |
Leptin binding inhibits the neuropeptide Y/agouti-related protein (NPY/AgRP) production and stimulates pro-opiomelanocortin (POMC) production |
|
| Publications: |
1 |
| Pathways: | Leptin Signaling |
| + |
AGRP | down-regulates activity 
binding
|
MC4R |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252379 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10318826 |
AGRP is a potent antagonist of the melanocortin-3 receptor and the MC4R and has also been shown to have a lesser degree of inhibitory action at the melanocortin-5 receptor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268709 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| Pathways: | Leptin Signaling |
| + |
AGRP | down-regulates
binding
|
MC4R |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51104 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9311920 |
Recombinant agouti-related protein was a potent, selective antagonist of mc3r and mc4r,. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
AGRP | down-regulates
binding
|
MC3R |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-51067 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9311920 |
Recombinant agouti-related protein was a potent, selective antagonist of mc3r and mc4r, melanocortin receptor subtypes implicated in weight regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
AGRP | down-regulates activity
binding
|
MC1R |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268699 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
FOXO1 | up-regulates quantity by expression 
transcriptional regulation
|
AGRP |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263501 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28270795 |
Foxo1 (when activated) stimulates the transcription of AgRP and NPY, but suppresses the transcription of POMC; thereby antagonizing the transcriptional action of STAT3 in these hypothalamic subpopulations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Leptin Signaling |
| + |
AGRP | down-regulates activity
binding
|
MC3R |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252380 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10318826 |
AGRP is a potent antagonist of the melanocortin-3 receptor and the MC4R and has also been shown to have a lesser degree of inhibitory action at the melanocortin-5 receptor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268704 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
AGRP | down-regulates activity
binding
|
MC2R |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268696 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and α, β, and γ melanocyte–stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AGRP | down-regulates activity
binding
|
MC5R |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268714 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
4.0
AGRP
- 
- 