Summary

Name AGRP
Full Name Agouti-related protein
Synonyms AGRP_HUMAN | AGRT, ART
Primary ID O00253
Links - -
Type protein
Relations 11
Pathways Leptin Signaling
Function Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png binding MC3R 0.618
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates quantity img/indirect_inhibition.png AGRP 0.471
Publications: 1
Pathways:Leptin Signaling
+ down-regulates activity img/direct_inhibition.png binding MC4R 0.768
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
Pathways:Leptin Signaling
+ down-regulates activity img/direct_inhibition.png binding MC3R 0.618
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation AGRP 0.458
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ down-regulates activity img/direct_inhibition.png binding MC2R 0.46
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MC1R 0.46
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png binding MC4R 0.768
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ down-regulates activity img/direct_inhibition.png binding MC5R 0.573
Publications: 1 Organism: Homo Sapiens
Tissue: Brain