Summary

Name TNFRSF11B
Full Name Tumor necrosis factor receptor superfamily member 11B
Synonyms Osteoclastogenesis inhibitory factor, Osteoprotegerin | OCIF, OPG, OCIF, OPG
Primary ID O00300
Links - -
Type protein
Relations 2
Function Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TNFRSF11B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TNFRSF11B 0.941
Publications: 1 Organism: Homo Sapiens