3.0
Summary
| Name |  PIK3C2AView Modifications |
| Full Name | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha |
| Synonyms | PI3K-C2-alpha, PtdIns-3-kinase C2 subunit alpha, Phosphoinositide 3-kinase-C2-alpha |
| Primary ID | O00443 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 | down-regulates activity 
phosphorylation
|
PIK3C2A | 0.285 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIK3C2A | up-regulates 
chemical modification
|
PIP3 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIK3C2A | up-regulates
chemical modification
|
PIPP | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IGF1R | up-regulates
phosphorylation
|
PIK3C2A | 0.278 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIK3C2A | up-regulates 
|
PLCG1 | 0.382 |
| Publications: | 1 | Organism: | Homo Sapiens | |