Summary

Name CHL1
Full Name Neural cell adhesion molecule L1-like protein
Synonyms Close homolog of L1 | CALL
Primary ID O00533
Links - -
Type protein
Relations 3
Function Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ CHL1up-regulates quantity img/direct-activation.png relocalization ANK2 0.419
Publications: 1 Organism: Rattus Norvegicus
Tissue: Central Nervous System
+ CHL1up-regulates quantity img/direct-activation.png relocalization ANK3 0.423
Publications: 1 Organism: Rattus Norvegicus
Tissue: Central Nervous System
+ CHL1up-regulates quantity img/direct-activation.png relocalization ANK1 0.505
Publications: 1 Organism: Rattus Norvegicus
Tissue: Central Nervous System