| + |
PPP6C | down-regulates activity 
dephosphorylation
|
CGAS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276990 |
Ser435 |
KHLDKFSsYHVKTAF |
Homo sapiens |
|
| pmid |
sentence |
| 32474700 |
In this study, we found that PPP6C suppressed phosphorylation of human cGAS (hcGAS) at S435 or mouse cGAS (mcGAS) at S420 in its substrate-binding pocket, thus preventing its binding to GTP and inhibiting the synthesis of cGAMP.|These data suggest that PPP6C inhibits cGAS activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP6C | up-regulates activity 
dephosphorylation
|
AGO2 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276516 |
Ser824 |
LVDKEHDsAEGSHTS |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 28114302 |
Our experiments demonstrated that target engagement by AGO2 stimulates its hierarchical, multi-site phosphorylation by CSNK1A1 on a series of highly conserved residues (S824-S834).Although this impairs target binding, dephosphorylation by ANKRD52-PPP6C allows AGO2 to engage new targets. Inactivation of this cycle strongly inhibits global miRNA-mediated repression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276517 |
Ser828 |
EHDSAEGsHTSGQSN |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 28114302 |
Our experiments demonstrated that target engagement by AGO2 stimulates its hierarchical, multi-site phosphorylation by CSNK1A1 on a series of highly conserved residues (S824-S834).Although this impairs target binding, dephosphorylation by ANKRD52-PPP6C allows AGO2 to engage new targets. Inactivation of this cycle strongly inhibits global miRNA-mediated repression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276513 |
Ser831 |
SAEGSHTsGQSNGRD |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 28114302 |
Our experiments demonstrated that target engagement by AGO2 stimulates its hierarchical, multi-site phosphorylation by CSNK1A1 on a series of highly conserved residues (S824-S834).Although this impairs target binding, dephosphorylation by ANKRD52-PPP6C allows AGO2 to engage new targets. Inactivation of this cycle strongly inhibits global miRNA-mediated repression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276514 |
Ser834 |
GSHTSGQsNGRDHQA |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 28114302 |
Our experiments demonstrated that target engagement by AGO2 stimulates its hierarchical, multi-site phosphorylation by CSNK1A1 on a series of highly conserved residues (S824-S834).Although this impairs target binding, dephosphorylation by ANKRD52-PPP6C allows AGO2 to engage new targets. Inactivation of this cycle strongly inhibits global miRNA-mediated repression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276515 |
Thr830 |
DSAEGSHtSGQSNGR |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 28114302 |
Our experiments demonstrated that target engagement by AGO2 stimulates its hierarchical, multi-site phosphorylation by CSNK1A1 on a series of highly conserved residues (S824-S834).Although this impairs target binding, dephosphorylation by ANKRD52-PPP6C allows AGO2 to engage new targets. Inactivation of this cycle strongly inhibits global miRNA-mediated repression. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
PPP6C | down-regulates activity
dephosphorylation
|
MAP3K7 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248292 |
Thr187 |
CDIQTHMtNNKGSAA |
Homo sapiens |
|
| pmid |
sentence |
| 17079228 |
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway|From proteomic analysis of TAK1-binding proteins, we identified protein phosphatase 6 (PP6), a type-2A phosphatase, and demonstrated that PP6 associated with and inactivated TAK1 by dephosphorylation of Thr-187. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP6C | down-regulates
dephosphorylation
|
MAP3K7 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150408 |
Thr187 |
CDIQTHMtNNKGSAA |
Homo sapiens |
|
| pmid |
sentence |
| 17079228 |
Our results demonstrate that pp6 specifically down-regulates tak1 through dephosphorylation of thr-187 in the activation loop, which is likely important for suppressing inflammatory responses via tak1 signaling pathways. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP6C | up-regulates activity
dephosphorylation
|
PRKDC |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277164 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19198648 |
In addition, siRNA knockdown of either PP6R1 or PP6 significantly decreased IR activation of DNA-PK, suggesting that PP6 activates DNA-PK by association and dephosphorylation.|PP6 may dephosphorylate sites in DNA-PKcs to reduce binding with heterodimer Ku proteins, because DNA-PK activation completely depends on Ku-mediated complex formation with DNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PPP6C
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