3.0
Summary
| Name |  PPP6CView Modifications |
| Full Name | Serine/threonine-protein phosphatase 6 catalytic subunit |
| Synonyms | PP6C | PPP6 |
| Primary ID | O00743 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation (PubMed:29053956). |
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dephosphorylation