| + |
TRAF2 | up-regulates activity 
ubiquitination
|
MAP3K7 |
0.579 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162638 |
Lys158 |
ALIHRDLkPPNLLLV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20038579 |
Tumor necrosis factor receptor-associated factors 2 and 6 (traf2 and -6) act as the ubiquitin e3 ligases to mediate lys63-linked tak1 polyubiquitination at the lys158 residue in vivo and in vitro. Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue is required for TAK1-mediated IKK complex recruitment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, P38 Signaling, SAPK/JNK Signaling |
| + |
TRIM8 | up-regulates activity
polyubiquitination
|
MAP3K7 |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271890 |
Lys158 |
ALIHRDLkPPNLLLV |
|
|
| pmid |
sentence |
| 22084099 |
These results suggest that TRIM8 could mediate K63-linked polyubiquitination of TAK1 at residue K158.These results suggest that TRIM8 is involved in TNFα- and IL-1β–induced NF-κB activation by mediating K63-linked TAK1 polyubiquitination and subsequent activation. |
|
| Publications: |
1 |
| + |
TRAF6 | up-regulates activity
ubiquitination
|
MAP3K7 |
0.889 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236071 |
Lys34 |
NFEEIDYkEIEVEEV |
Homo sapiens |
|
| pmid |
sentence |
| 18758450 |
Intriguingly, TGF-beta-induced TRAF6-mediated Lys 63-linked polyubiquitylation of TAK1 Lys 34 correlates with TAK1 activation. Our data show that TGF-beta specifically activates TAK1 through interaction of TbetaRI with TRAF6, whereas activation of Smad2 is not dependent on TRAF6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, NF-KB Canonical, P38 Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV INFLAMMATORY RESPONSE, TGF-beta Signaling, Toll like receptors |
| + |
MAP3K7 | down-regulates 
phosphorylation
|
HDAC7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149579 |
Ser155 |
FPLRKTVsEPNLKLR |
Homo sapiens |
|
| pmid |
sentence |
| 16980613 |
We further show that emk and c-tak1 phosphorylate class iia hdacs on one of their multiple 14-3-3 binding sites and alter their subcellular localization and repressive function |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
IKBKB |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109490 |
Ser177 |
AKELDQGsLCTSFVG |
Homo sapiens |
|
| pmid |
sentence |
| 11460167 |
Tak1 become activated and then phosphorylates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation. tak1 kinase complex phosphorylates and activates ikk in a manner that depends on traf6 and ubc13-uev1a our studies suggests that tak1_ acts as an upstream activating kinase for ikkbeta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109494 |
Ser181 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
| pmid |
sentence |
| 11460167 |
Tak1 become activated and then phosphorylates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation. tak1 kinase complex phosphorylates and activates ikk in a manner that depends on traf6 and ubc13-uev1a our studies suggests that tak1_ acts as an upstream activating kinase for ikkbeta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19632174 |
Tak1 become activated and then phosphorylates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation. tak1 kinase complex phosphorylates and activates ikk in a manner that depends on traf6 and ubc13-uev1a our studies suggests that tak1_ acts as an upstream activating kinase for ikkbeta. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP3K7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232153 |
Ser192 |
HMTNNKGsAAWMAPE |
in vitro |
|
| pmid |
sentence |
| 20538596 |
Analyses of phosphorylation site mutants of the activation segment indicate that autophosphorylation of Ser-192 precedes TAB1 phosphorylation and is followed by sequential phosphorylation of Thr-178, Thr-187, and finally Thr-184. Finally, we present a model for the chronological order of events governing TAB1-induced TAK1 autoactivation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235758 |
Ser192 |
HMTNNKGsAAWMAPE |
Homo sapiens |
|
| pmid |
sentence |
| 10702308 |
A mutant of TAK1 that lacks kinase activity is not phosphorylated either following IL-1 treatment or when coexpressed with TAB1, indicating that TAK1 phosphorylation is due to autophosphorylation. Furthermore, mutation to alanine of a conserved serine residue (Ser-192) in the activation loop between kinase domains VII and VIII abolishes both phosphorylation and activation of TAK1. These results suggest that IL-1 and ectopic expression of TAB1 both activate TAK1 via autophosphorylation of Ser-192. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227536 |
Thr178 |
LKICDFGtACDIQTH |
in vitro |
|
| pmid |
sentence |
| 20538596 |
Analyses of phosphorylation site mutants of the activation segment indicate that autophosphorylation of Ser-192 precedes TAB1 phosphorylation and is followed by sequential phosphorylation of Thr-178, Thr-187, and finally Thr-184. Finally, we present a model for the chronological order of events governing TAB1-induced TAK1 autoactivation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227544 |
Thr184 |
GTACDIQtHMTNNKG |
in vitro |
|
| pmid |
sentence |
| 20538596 |
Analyses of phosphorylation site mutants of the activation segment indicate that autophosphorylation of Ser-192 precedes TAB1 phosphorylation and is followed by sequential phosphorylation of Thr-178, Thr-187, and finally Thr-184. Finally, we present a model for the chronological order of events governing TAB1-induced TAK1 autoactivation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227540 |
Thr187 |
CDIQTHMtNNKGSAA |
in vitro |
|
| pmid |
sentence |
| 20538596 |
Analyses of phosphorylation site mutants of the activation segment indicate that autophosphorylation of Ser-192 precedes TAB1 phosphorylation and is followed by sequential phosphorylation of Thr-178, Thr-187, and finally Thr-184. Finally, we present a model for the chronological order of events governing TAB1-induced TAK1 autoactivation. |
|
| Publications: |
5 |
Organism: |
In Vitro, Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, SARS-CoV INFLAMMATORY RESPONSE, TGF-beta Signaling, Toll like receptors |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
ATAT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272243 |
Ser237 |
GDIKPYSsSDREFLK |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 29703898 |
Here we report TGF-beta-activated kinase 1 (TAK1) as a key activator of alphaTAT1. TAK1 directly interacts with and phosphorylates alphaTAT1 at Ser237 to critically enhance its catalytic activity |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
MAP3K7 | down-regulates quantity by destabilization
phosphorylation
|
TNFAIP8L2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273668 |
Ser3 |
sFSSKSLA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32188758 |
TAK1 phosphorylated the Ser3 in the noncanonical degron motif of TIPE2 to trigger its interaction with β-TrCP for subsequent ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 |
phosphorylation
|
PTPN3 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-52781 |
Ser359 |
PAMRRSLsVEHLETK |
Homo sapiens |
|
| pmid |
sentence |
| 9341175 |
Mutation of ser359 and ser853 to alanine significantly reduced the association between 14-3-3beta and ptph1. Furthermore, association of ptph1 and 14-3-3beta was detected in several cell lines and was regulated in response to extracellular signals |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | down-regulates
phosphorylation
|
KSR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112779 |
Ser406 |
TRLRRTEsVPSDINN |
Homo sapiens |
|
| pmid |
sentence |
| 11741534 |
C-tak1 constitutively associates with mammalian ksr1 and phosphorylates serine 392 to confer 14-3-3 binding and cytoplasmic sequestration of ksr1 in unstimulated cells. In response to signal activation, the phosphorylation state of s392 is reduced, allowing the ksr1 complex to colocalize with activated ras and raf-1 at the plasma membrane |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
TAB1 |
0.927 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276364 |
Ser452 |
STNTHTQsSSSSSDG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22216226 |
We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact cells as well as in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276366 |
Ser453 |
TNTHTQSsSSSSDGG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22216226 |
We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact cells as well as in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276365 |
Ser456 |
HTQSSSSsSDGGLFR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22216226 |
We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact cells as well as in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276367 |
Ser457 |
TQSSSSSsDGGLFRS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22216226 |
We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact cells as well as in vitro. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
PPP6C | down-regulates
dephosphorylation
|
MAP3K7 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150408 |
Thr187 |
CDIQTHMtNNKGSAA |
Homo sapiens |
|
| pmid |
sentence |
| 17079228 |
Our results demonstrate that pp6 specifically down-regulates tak1 through dephosphorylation of thr-187 in the activation loop, which is likely important for suppressing inflammatory responses via tak1 signaling pathways. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | down-regulates
dephosphorylation
|
MAP3K7 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150369 |
Thr187 |
CDIQTHMtNNKGSAA |
Homo sapiens |
|
| pmid |
sentence |
| 17079228 |
Our results demonstrate that pp6 specifically down-regulates tak1 through dephosphorylation of thr-187 in the activation loop, which is likely important for suppressing inflammatory responses via tak1 signaling pathways. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
PPP6C | down-regulates activity
dephosphorylation
|
MAP3K7 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248292 |
Thr187 |
CDIQTHMtNNKGSAA |
Homo sapiens |
|
| pmid |
sentence |
| 17079228 |
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway|From proteomic analysis of TAK1-binding proteins, we identified protein phosphatase 6 (PP6), a type-2A phosphatase, and demonstrated that PP6 associated with and inactivated TAK1 by dephosphorylation of Thr-187. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
RAB8A |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260266 |
Thr72 |
AGQERFRtITTAYYR |
in vitro |
|
| pmid |
sentence |
| 32227113 |
In a screen for Rab8A kinases we identify TAK1 and MST3 kinases that can efficiently phosphorylate the Switch II residue Threonine72 (Thr72) in a similar manner as LRRK2 in vitro. |Overall our data suggests that the phosphorylation of Rab8A at Ser111 may influence Switch II-binding by regulators, thus disrupting interactions with its cognate GEF and moderately impairs its interaction with GAPs.|The antagonistic interplay between Ser111 phosphorylation and Thr72 phosphorylation is genetically concordant with how respective mutations in PINK1 and LRRK2 cause Parkinson’s disease |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
RAB1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277270 |
Thr75 |
AGQERFRtITSSYYR |
in vitro |
|
| pmid |
sentence |
| 27482120 |
TAK1 preferentially phosphorylates the inactive (GDP-bound) state of Rab1. Phosphorylation of Rab1 disrupts interaction with GDP dissociation inhibitor 1 (GDI1), but not guanine exchange factor (GEF) or GTPase-activating protein (GAP) enzymes, and is exclusive to membrane-localized Rab1, suggesting phosphorylation may stimulate Rab1 membrane association. Furthermore, we found phosphorylation of Rab1 at T75 to be essential for Rab1 function. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPM1B | down-regulates activity
dephosphorylation
|
MAP3K7 |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277154 |
|
|
in vitro |
|
| pmid |
sentence |
| 11104763 |
In vitro, PP2Cbeta-1 dephosphorylated and inactivated TAK1. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CDON/SPAG9 |
binding
|
MAP3K7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235560 |
|
|
Mus musculus |
C2C12 Cell, Myoblast, HEK-293T Cell |
| pmid |
sentence |
| 22337877 |
Cdo and jlp interacted with ask1 or tak1 in 293t cells and c2c12 myoblasts |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAP3K7 | down-regulates
phosphorylation
|
NFKBIB |
0.494 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9480845 |
Overexpression oftak1together with its activator protein,tak1binding protein 1 (tab1), induced thenucleartranslocation of nf-kappa b p50/p65 heterodimer accompanied by the degradation of i kappa b alpha and i kappa b beta, and the expression of kappa b-dependent reporter gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAB2 | up-regulates activity
binding
|
MAP3K7 |
0.934 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-120268 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14670075 |
Our results indicate that two distinct TAK1 complexes are present in cells. One comprises TAK1 complexed with TAB1 and TAB2, and the other TAK1 complexed with TAB1 and TAB3. Both complexes are activated in response to tumour necrosis factor-alpha or interleukin-1 in human epithelial KB cells or bacterial lipopolysaccharide in RAW264.7 macrophages |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105860 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8638164 |
The yeast two-hybrid system has now revealed two human proteins, termed tab1 and tab2 (for tak1 binding protein), that interact with tak1. Overproduction of tab1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by tgf-beta, and increased the kinase activity of tak1. . These results define tab2 as an adaptor linking tak1 and traf6 and as a mediator of tak1 activation in the il-1 signaling pathway . taken together, these results indicate that polyubiquitination of rip1 mediates the independent recruitment of tab2 and nemo, which in turn recruits tak1 and ikk, respectively, to tnf-r1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119370 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14633987 |
These results suggest that TAB2 and TAB3 function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling , NF-KB Canonical, P38 Signaling and Myogenesis |
| + |
TAB3 | up-regulates activity
binding
|
MAP3K7 |
0.826 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-120325 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14670075 |
We have identified a new binding partner of the tgfbeta (transforming growth factor-beta)-activated protein kinase (tak1), termed tab.two distinct tak1 complexes are present in cells. One comprises tak1 complexed with tab1 and tab2, and the other tak1 complexed with tab1 and tab3 (tak1-binding protein-3). Both complexes are activated in response to tumour necrosis factor-alpha or interleukin-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NF-KB Canonical |
| + |
MAP3K7 | up-regulates
phosphorylation
|
IKK-complex |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217445 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11460167 |
Tak1 kinase complex phosphorylates and activates ikk in a manner that depends on traf6 and ubc13-uev1a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP3K14 |
0.544 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262833 |
|
|
|
|
| pmid |
sentence |
| 10094049 |
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway|Activated TAK1 phosphorylates NIK, which stimulates IKK-alpha activity. Our results indicate that TAK1 links TRAF6 to the NIK-IKK cascade in the IL-1 signalling pathway. |
|
| Publications: |
1 |
| + |
CDON |
binding
|
MAP3K7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235554 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22337877 |
Cdo and jlp interacted with ask1 or tak1 in 293t cells and c2c12 myoblasts |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP2K7 |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274146 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17110930 |
Upon TNFα stimulation, MEKK1, ASK1, and TAK1 phosphorylate and activate MKK7, which in turn activates JNK |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Toll like receptors |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP2K6 |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236145 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Tak1 can phosphorylate and activate map kinase kinase 3/6 (mkk3/6), and numerous studies have demonstrated a requirement for mkk3/6 activity in the initiation of myoblast differentiation, again in a p38-dependent manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11460167 |
The activity of tak1 to phosphorylate mkk6, which activates the jnk-p38 kinase pathway, is directly regulated by k63-linked polyubiquitination |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
IKK-complex |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209759 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21232017 |
Tak1 become activated and then phosphorilates and activates ikk2 whic in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256024 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21133840 |
RIP-1 recruitment of MEKK-3 and transforming growth factor-beta (TGFbeta)-activated kinase (TAK1) subsequently activates the IKK (inhibitor of κB kinase) complex |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors |
| + |
MAP4K1 | up-regulates 
|
MAP3K7 |
0.536 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67321 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10224067 |
These studies establish that hpk1 acts as an upstream activator for the tak1-sek-jnk1 module in relaying the tgf-_ signal into the nuclei in 293t cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, SAPK/JNK Signaling |
| + |
IL1RL1 | up-regulates activity
binding
|
MAP3K7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277716 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35238669 |
The activated heterodimer complex recruits downstream signaling components, including myeloid differentiation primary response protein 88 (MyD88), IL-1 receptor (IL-1R)–associated kinase, tumor necrosis factor (TNF) receptor–associated factor 6 (TRAF6), and transforming growth factor (TGF)-β–activated kinase 1 (TAK1) complex, resulting in TAK1 activation. TAK1 subsequently activates downstream kinases inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKα) and IKKβ, which phosphorylate nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibitor (IκB) proteins. These events ultimately lead to activation of the transcription factor NF-κB and induction of downstream effector genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42402 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17299140 |
Taken together, our data indicate that TAK1 and TAB1 play a pivotal role as upstream signal transducers activating the MKK3-p38 MAPK signaling cascade that leads to the induction of type I collagen expression by TGF-beta(1). In addition, our findings also suggest that TAK1 has a novel function in regulation of the steady-state protein levels of MKK3 and p38 MAPK. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236093 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 21902831 |
TAK1 can phosphorylate and activate MAP kinase kinase 3/6 (MKK3/6), and numerous studies have demonstrated a requirement for MKK3/6 activity in the initiation of myoblast differentiation, again in a p38-dependent manner. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling, Toll like receptors |
| + |
MAP3K7 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-50618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9278437 |
Mitogen-activated protein kinase kinase 4 (mkk4)/stress-activated protein kinase/extracellular signal-regulated kinase (sek1), a dual-specificity kinase that phosphorylates and activates jnk, synergized with tak1 in activating jnk.Taken together, these results identify TAK1 as a regulator in the HPK1 --> TAK1 --> MKK4/SEK1 --> JNK kinase cascade and indicate the involvement of JNK in the TGF-beta signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, P38 Signaling, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV MAPK PERTURBATION, TGF-beta Signaling |
| + |
TAB1 | up-regulates activity
binding
|
MAP3K7 |
0.927 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17299140 |
The yeast two-hybrid system has now revealed two human proteins, termed tab1 and tab2 (for tak1 binding protein), that interact with tak1. Overproduction of tab1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by tgf-beta, and increased the kinase activity of tak1. Tab1 activates the kinase activity of tak1 by directly binding to its catalytic domain. Tab1 overexpression increase the kinase activity of tak1 in mammalian cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-41941 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8638164 |
The yeast two-hybrid system has now revealed two human proteins, termed tab1 and tab2 (for tak1 binding protein), that interact with tak1. Overproduction of tab1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by tgf-beta, and increased the kinase activity of tak1. Tab1 activates the kinase activity of tak1 by directly binding to its catalytic domain. Tab1 overexpression increase the kinase activity of tak1 in mammalian cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
SPAG9 |
binding
|
MAP3K7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235548 |
|
|
Mus musculus |
C2C12 Cell, Myoblast, HEK-293T Cell |
| pmid |
sentence |
| 22337877 |
Cdo and jlp interacted with ask1 or tak1 in 293t cells and c2c12 myoblasts |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAP3K7 | up-regulates activity
binding
|
IKBKG |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162634 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20038579 |
This result suggests that ikkgamma/nemo binds to the polyubiquitinated tak1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors |
| + |
PPM1F | down-regulates activity
dephosphorylation
|
MAP3K7 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277047 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28906490 |
However, our current work shows that POPX2 can downregulate TAK1 and affect the anti-apoptotic activities of TAK1, implying that silencing POPX2 could facilitate TAK1 activation and will lead to increased cell survival.|We have also demonstrated that POPX2 can directly dephosphorylate TAK1 (XREF_FIG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP4K4 | up-regulates
binding
|
MAP3K7 |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77404 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10807933 |
The existence of an at least trimolecular complex consisting of nik, tak1, and ikk2, although the precise sequence of activation as well as the possible location of the kinases within the signalosome remains to be elucidated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates
phosphorylation
|
NLK |
0.635 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96425 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12482967 |
The tak1-nlk-mapk-related pathway antagonizes signalling between beta-catenin and transcription factor tcf. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
|
NfKb-p65/p50 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55710 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9480845 |
Overexpression of tak1 together with its activator protein, tak1 binding protein 1 (tab1), induced the nuclear translocation of nf-kappa b p50/p65 heterodimer accompanied by the degradation of i kappa b alpha and i kappa b beta, and the expression of kappa b-dependent reporter gene...[]...These Results suggest that tak1 induces nf-kappa b activation through a novel nik-independent signaling pathway |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inflammosome Activation, Inhibition of Apoptosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors |
| + |
MAP3K7 | down-regulates quantity by destabilization 
|
NFKBIA |
0.658 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55716 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9480845 |
Overexpression of tak1 together with its activator protein, tak1 binding protein 1 (tab1), induced the nuclear translocation of nf-kappa b p50/p65 heterodimer accompanied by the degradation of i kappa b alpha and i kappa b beta, and the expression of kappa b-dependent reporter gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, EBV infection, IL1 Signaling , Inhibition of Apoptosis, NF-KB Canonical, Toll like receptors |
| + |
BMPR1A | up-regulates activity
|
MAP3K7 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255815 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 8533096 |
We also examined whether TAK1 was activated by bone morphogenetic protein (BMP). BMP-4 also stimulated TAK1 activity in a time- and dose-dependent manner |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPM1L | down-regulates activity
dephosphorylation
|
MAP3K7 |
0.604 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277114 |
|
|
in vitro |
|
| pmid |
sentence |
| 12556533 |
Co-immunoprecipitation experiments indicated that PP2Cepsilon associates stably with TAK1 and attenuates the binding of TAK1 to MKK4 or MKK6.|PP2Cepsilon dephosphorylated TAK1 in vitro. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SMAD6 | down-regulates activity
binding
|
MAP3K7 |
0.551 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235571 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11737269 |
Smad6 interacts with tak1 and tab1, and smad7 with tab1. The interaction of i-smads with tak1 and/or tab1 implies that several mechanisms exist underlying the repression of the tak1-p38 kinase pathway by i-smads. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | TGF-beta Signaling |
| + |
MAP3K7 | up-regulates quantity by expression
transcriptional regulation
|
NFKB1 |
0.581 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55713 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9480845 |
These results suggest that tak1 induces nf-kappa b activation through a novel nik-independent signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMK2G | up-regulates
phosphorylation
|
MAP3K7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96422 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12482967 |
Camkii interacts with and phosphorylates tak1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CYLD | up-regulates activity
deubiquitination
|
MAP3K7 |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266437 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29291351 |
Mechanistically, CYLD interacts directly with the kinase TAK1 and removes its K63-linked polyubiquitin chain, which blocks downstream activation of the JNK-p38 cascades. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NF-KB Canonical |
| + |
PTPN6 | down-regulates activity
dephosphorylation
|
MAP3K7 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31130074 |
Mechanistically, the association of EHEC Tir with SHP-1 facilitated the recruitment of SHP-1 to TAK1 and inhibited TAK1 phosphorylation, which then negatively regulated K63-linked polyubiquitination of TAK1 and downstream signal transduction.|SHP-1 inhibits TAK1 activity to down-regulate signal transduction and subsequent cytokine production.Innate immune responses are achieved by the activation of several pathogen-recognition receptors (PRPs), including TLRs, retinoic acid inducible gene I (RIG-I)-like receptors (RLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP3K7 | up-regulates activity
|
MAP3K4 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-63979 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9890973 |
These results indicate that hgk, a novel activator of the jnk pathway, may function through tak1, and that the hgk --> tak1 --> mkk4, mkk7 --> jnk kinase cascade may mediate the TNF-alphalpha signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
RIPK1 | up-regulates activity
binding
|
MAP3K7 |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256022 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21133840 |
RIP-1 recruitment of MEKK-3 and transforming growth factor-beta (TGFbeta)-activated kinase (TAK1) subsequently activates the IKK (inhibitor of κB kinase) complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Inflammosome Activation, NF-KB Canonical, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV INFLAMMATORY RESPONSE |
3.0
MAP3K7
- 
- 