Summary

Name ARID1A
Full Name AT-rich interactive domain-containing protein 1A
Synonyms ARID domain-containing protein 1A, B120, BRG1-associated factor 250, BAF250, BRG1-associated factor 250a, BAF250A, Osa homolog 1, hOSA1, SWI-like protein, SWI/SNF complex protein p270, SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1, hELD | BAF250, BAF250A, C1orf4, OSA1, SMARCF1
Primary ID O14497
Links - -
Type protein
Relations 8
Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ ARID1Aform complex img/form-complex.png binding SWI/SNF ACTL6A-ARID1A-SMARCA2 variant 0.801
Publications: 1 Organism: Homo Sapiens
+ ARID1Aform complex img/form-complex.png binding Brain-specific SWI/SNF SMARCA2 variant 0.749
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ ARID1Aform complex img/form-complex.png binding Neural progenitor-specific SWI/SNF 0.801
Publications: 1 Organism: Homo Sapiens
+ ARID1Aform complex img/form-complex.png binding Muscle cell-specific SWI/SNF SMARCA4 variant 0.78
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ ARID1Aform complex img/form-complex.png binding SWI/SNF complex 0.786
Publications: 1 Organism: Homo Sapiens
+ ARID1Aform complex img/form-complex.png binding Embryonic stem cell-specific SWI/SNF 0.729
Publications: 1 Organism: Mus Musculus
+ ARID1Aform complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1A variant 0.799
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ ARID1Aform complex img/form-complex.png binding Brain-specific SWI/SNF SMARCA4 variant 0.758
Publications: 1 Organism: Homo Sapiens
Tissue: Brain