| + |
SWI/SNF complex | down-regulates 
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256298 |
|
|
Homo sapiens |
G-401 Cell |
| pmid |
sentence |
| 12226744 |
The hSNF5/INI1 gene encodes a member of the SWI/SNF chromatin remodelling complexes.Here, we show that the ectopic expression of wild-type hSNF5/INI1, but not that of truncated versions, leads to a cell cycle arrest by inhibiting the entry into S phase of MRT cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID1B | form complex 
binding
|
SWI/SNF complex |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241713 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPF2 | up-regulates activity 
binding
|
SWI/SNF complex |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261963 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20460684 |
Our current findings indicate that REQ is a novel adaptor protein that links the Brm-type SWI/SNF complex and RelB/p52 and operates at the most downstream stages of the noncanonical NF-κB pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SWI/SNF complex | up-regulates quantity by expression 
transcriptional regulation
|
CDKN2B |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256300 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18332116 |
HSNF5 reexpression in MRT cells caused SWI/SNF recruitment and activation of p15INK4b and p16INK4a, but not of p14ARF.Reexpression of hSNF5 in MRT cells overcomes epigenetic silencing and mediates transcriptional activation of p15INK4b and p16INK4a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID2 | form complex
binding
|
SWI/SNF complex |
0.721 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241756 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMARCC1 | form complex
binding
|
SWI/SNF complex |
0.863 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132933 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMARCA4 | form complex
binding
|
SWI/SNF complex |
0.915 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132922 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SWI/SNF complex | up-regulates
|
Epigenetic_regulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268623 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33941852 |
Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SWI/SNF complex | up-regulates activity
binding
|
TP53 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256285 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 11950834 |
Using genetic and biochemical approaches, we show that several subunits of the human SWI/SNF complex bind to the tumor suppressor protein p53 in vivo and in vitro.Molecular connection between p53 and the SWI/SNF complex implicates that (i) the SWI/SNF complex is necessary for p53-driven transcriptional activation, and (ii) the SWI/SNF complex plays an important role in p53-mediated cell cycle control. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYOG | up-regulates
binding
|
SWI/SNF complex |
0.32 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217740 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Upon the expression of myogenin, myogenin, mef2d, and brg1 localize to the myogenin promoter to maintain myogenin expression./ Swi/snf chromatin-remodeling activity is required for myogenin expression in differentiated skeletal muscle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
SWI/SNF complex | down-regulates quantity by repression
transcriptional regulation
|
CCND1 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256293 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12138206 |
INI1/hSNF5 is a component of the ATP-dependent chromatin remodeling hSWI/SNF complex [.]. Our data suggest that one of the mechanisms by which INI1/hSNF5 exerts its tumor suppressor function is by mediating the cell cycle arrest due to the direct recruitment of HDAC activity to the cyclin D1 promoter thereby causing its repression and G(0)-G(1) arrest. These results together indicate that cyclin D1 is a direct target for repression by INI1/hSNF5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACTL6A | form complex
binding
|
SWI/SNF complex |
0.852 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132916 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMARCE1 | form complex
binding
|
SWI/SNF complex |
0.884 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132942 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SWI/SNF complex | up-regulates activity
binding
|
RUNX1 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261965 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20506188 |
Our findings indicate that RUNX1 interacts with the human SWI/SNF complex to control hematopoietic-specific gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID1A | form complex
binding
|
SWI/SNF complex |
0.792 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132919 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SWI/SNF complex | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256292 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16452181 |
C-myc is a direct target of SWI/SNF complex–dependent promoter repression. These results indicate that repression of c-myc is indeed dependent on the activity of SWI/SNF–related complexes and specifically on complexes that contain ARID1A. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMARCD1 | form complex
binding
|
SWI/SNF complex |
0.886 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132939 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYOD1 | up-regulates
binding
|
SWI/SNF complex |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217737 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Myod targets brg1 to the myogenin promoter during the initiation of myogenesis in tissue culture models for skeletal muscle differentiation /initiation of myogenin transcription is dependent upon myod, the pbx homeodomain factor, and swi/snf chromatin-remodeling enzymes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
CIC | up-regulates activity
binding
|
SWI/SNF complex |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269207 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32229723 |
Mechanistically, we demonstrated that CIC represses VGF expression by tethering SIN3-HDAC to form a transcriptional corepressor complex. Mass spectrometry analysis of CIC-interacting proteins further identified the BRG1-containing mSWI/SNF complex whose function is necessary for transcriptional repression by CIC. CIC interacts with mSWI/SNF complex during neurogenesis. CIC tethers SIN3-HDAC corepressor complex and mSWI/SNF complex to VGF promoter during neurogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
SMARCC2 | form complex
binding
|
SWI/SNF complex |
0.87 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SWI/SNF complex | up-regulates quantity by expression
transcriptional regulation
|
CDKN2A |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256299 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18332116 |
HSNF5 reexpression in MRT cells caused SWI/SNF recruitment and activation of p15INK4b and p16INK4a, but not of p14ARF.Reexpression of hSNF5 in MRT cells overcomes epigenetic silencing and mediates transcriptional activation of p15INK4b and p16INK4a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SWI/SNF complex | form complex
binding
|
Myog/SWI/SNF complex |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151706 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Upon the expression of myogenin, myogenin, mef2d, and brg1 localize to the myogenin promoter to maintain myogenin expression./ Swi/snf chromatin-remodeling activity is required for myogenin expression in differentiated skeletal muscle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
SWI/SNF complex | form complex
binding
|
MYOD1/SWI/SNF complex |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151703 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Myod targets brg1 to the myogenin promoter during the initiation of myogenesis in tissue culture models for skeletal muscle differentiation /initiation of myogenin transcription is dependent upon myod, the pbx homeodomain factor, and swi/snf chromatin-remodeling enzymes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
SMARCB1 | form complex
binding
|
SWI/SNF complex |
0.898 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132930 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15627498 |
We discuss recent insights in the functional differences between two evolutionary conserved subclasses of swi/snf-related chromatin remodeling factors. Onesubfamily comprises yeast swi/snf, fly bap and mammalian baf, whereas the other subfamily includes yeast rsc, fly pbap andmammalian pbaf. We review the subunit composition, conserved protein modules and biological functions of each of these subclasses ofswi/snf remodelers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADNP | up-regulates quantity
binding
|
SWI/SNF complex |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266757 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17878164 |
ADNP Co-precipitates with the SWI/SNF Complex through ADNP C-terminal Interaction. Down-regulation of ADNP by shRNA resulted in morphological changes that are in line with the fact that ADNP contains a homeodomain profile (2) and with the SWI/SNF complex function that is associated with cellular differentiation. Our results suggest that ADNP functionality plays a role in these changes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
SWI/SNF complex