Summary

Name NRG2
Full Name Pro-neuregulin-2, membrane-bound isoform
Synonyms Pro-NRG2 | NTAK
Primary ID O14511
Links - -
Type protein
Relations 3
Function Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding ERBB4 0.78
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding ERBB3 0.814
Publications: 1 Organism: Homo Sapiens