| + |
BACH1 | up-regulates quantity 
transcriptional regulation
|
GAPDH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259339 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31257027 |
BACH1 activates transcription of Hexokinase 2 and Gapdh and increases glucose uptake, glycolysis rates, and lactate secretion, thereby stimulating glycolysis-dependent metastasis of mouse and human lung cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BACH1 | down-regulates quantity 
transcriptional regulation
|
HMOX1 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259336 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14747657 |
These results indicate that ho-1 regulation involves a competition between the activator Nrf2 and the Bach1 repressor for interactions with the small Maf proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BACH1 | up-regulates activity
binding
|
MAFK |
0.486 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226409 |
|
|
Mus musculus |
MEL Cell |
| pmid |
sentence |
| 19011633 |
Bach1 forms a heterodimer with the small Maf oncoproteins and binds to the Maf-recognition element (MARE) to inhibit target genes |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BACH1 | up-regulates 
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259337 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22875853 |
Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXO22 | down-regulates quantity
ubiquitination
|
BACH1 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259331 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31257023 |
Here, we show that heme triggers the degradation of Bach1, a pro-metastatic transcription factor, by promoting its interaction with the ubiquitin ligase Fbxo22. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBCK1 | down-regulates quantity by destabilization
ubiquitination
|
BACH1 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236971 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17682061 |
HOIL-1 bound Bach1 in vivo and thus stimulated its polyubiquitination in vitro. These results suggest that heme regulates the polyubiquitination of Bach1 and subsequent degradation and that HOIL-1 may function as an E3 ligase in this process. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BACH1 | up-regulates quantity
transcriptional regulation
|
HK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259338 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31257027 |
BACH1 activates transcription of Hexokinase 2 and Gapdh and increases glucose uptake, glycolysis rates, and lactate secretion, thereby stimulating glycolysis-dependent metastasis of mouse and human lung cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BACH1 | up-regulates quantity
transcriptional regulation
|
Hexokinase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270266 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31257027 |
BACH1 activates transcription of Hexokinase 2 and Gapdh and increases glucose uptake, glycolysis rates, and lactate secretion, thereby stimulating glycolysis-dependent metastasis of mouse and human lung cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BACH1
- 
- 