| + |
EREG | up-regulates 
binding
|
ErbB receptor family |
0.891 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269873 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16829981 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADAM17 | up-regulates activity
cleavage
|
EREG |
0.548 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26284334 |
ADAM17 is involved in the release and activation of several growth factors and cytokine receptor ligands. Among the growth factors activated by ADAM17 are TGF-alpha, amphiregulin, epiregulin and HB-EGF |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EREG | up-regulates
binding
|
ERBB3 |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147856 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16829981 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191785 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22891299 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
EREG | up-regulates
binding
|
ERBB4 |
0.695 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191788 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22891299 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16829981 |
For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
EREG | up-regulates
binding
|
EGFR |
0.889 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20513444 |
Remarkably, three members of the epidermal growth factor (egf) family (ereg, areg, and epgn) showed increased expression that was associated with elevated epidermal activation of the egf receptor (egfr) and stat3, a downstream effector of egfr signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-54351 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 9419975 |
Chemical cross-linking experiments showed that [125i]epiregulin directly bound to each of egfr and erbb-4 but not to erbb-2 and erbb-3. remarkably, three members of the epidermal growth factor (egf) family (ereg, areg, and epgn) showed increased expression that was associated with elevated epidermal activation of the egf receptor (egfr) and stat3, a downstream effector of egfr signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
3.0
EREG
- 
- 