Summary

Name EGFR
Full Name Epidermal growth factor receptor
Synonyms Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 | ERBB, ERBB1, HER1
Primary ID P00533
Links - -
Type protein
Relations 302
Pathways Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, FLT3-ITD in AML, Glioblastoma Multiforme, GPCR_CRC, GPCR_HCC, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), SARS-CoV MAPK PERTURBATION
Inhibitors lapatinib; 9-(1-Methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone; vandetanib; VARLITINIB; afatinib; erlotinib; canertinib; PD-153035 hydrochloride; N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-6-quinazolinyl]-2-propenamide; BMS-599626; tyrphostin B42; erlotinib hydrochloride; 873837-23-1; CUDC-101; dacomitinib; WZ4002; AV412; gefitinib; neratinib; tyrphostin AG 1478; XL-647; sapitinib; pelitinib; OSI-420
Function Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.427
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation SPRED1 0.272
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.372
Publications: 7 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.394
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.363
Publications: 2 Organism: , Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DOCK1 0.308
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ABCA1 0.295
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PELI1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.369
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.608
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.638
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.556
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, FLT3-ITD in AML, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates img/direct_inhibition.png phosphorylation CALM1 0.405
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALM2 0.346
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALM3 0.383
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.624
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.759
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.87
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Noonan syndrome
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.2
Publications: 13 Organism: Mus Musculus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, FLT3-ITD in AML, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PPARG 0.514
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ZNRF1 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.612
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Acute Myeloid Leukemia, EGFR Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.482
Publications: 1 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation EGFR 0.491
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation KCNN1 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation EGFR 0.615
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.624
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.42
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation EGFR 0.482
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation EGFR 0.416
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.613
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MUC1 0.578
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERBB2 0.613
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLCG1 0.84
Publications: 4 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation ERBB3 0.671
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRK2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GLUD1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KCND3 0.2
Publications: 2 Organism: Homo Sapiens,
+ up-regulates img/direct-activation.png phosphorylation VAV2 0.593
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CTNNB1 0.772
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, Hepatocellular Tumor, Pancreatic ductal adenocarcinoma (PDA)
+ img/unknown.png phosphorylation EZR 0.53
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PKM 0.449
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IKBKE 0.258
Publications: 4 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates activity img/direct-activation.png phosphorylation GNAI1 0.462
Publications: 3 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation RGS16 0.415
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLD2 0.517
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation STAM2 0.605
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.595
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GSTP1 0.438
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB2 0.923
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ up-regulates img/direct-activation.png phosphorylation ANXA1 0.509
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PCNA 0.342
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CCDC50 0.416
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC3 (isoform 2) 0.617
Publications: 4 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CRK 0.74
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CTNND1 0.64
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BECN1 0.521
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KCNJ4 0.2
Publications: 1 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation SOX2 0.479
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GAB1 0.76
Publications: 5 Organism: Homo Sapiens
Pathways:EGFR Signaling, Hepatocellular Tumor, Noonan syndrome, PI3K/AKT Signaling
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.76
Publications: 4 Organism: In Vitro, Homo Sapiens
Pathways:EGFR Signaling, Hepatocellular Tumor, Noonan syndrome, PI3K/AKT Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation GPRC5A 0.386
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LYN 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HGS 0.636
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HGS 0.636
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ASAP3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EZR 0.53
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCAMP1 0.336
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ATM 0.398
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation AGO2 0.535
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERRFI1 0.643
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation SCAMP3 0.4
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation SCAMP3 0.4
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation SQSTM1 0.33
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RASA1 0.654
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.87
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Noonan syndrome
+ up-regulates quantity img/direct-activation.png phosphorylation TRIP13 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC6 0.441
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NIBAN2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPN1 0.759
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EPB41 0.401
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT5B 0.829
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation USP8 0.71
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5B 0.829
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AXL 0.431
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PKIA 0.308
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EPS15 0.754
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TLR3 0.426
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation LRRK1 0.343
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity img/direct_inhibition.png binding EGFR 0.448
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.737
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates img/direct-activation.png binding EGFR 0.766
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png relocalization EGFR 0.523
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.781
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, FLT3-ITD in AML, Hepatocellular Tumor, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.59
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.879
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination EGFR 0.71
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STAT5A 0.821
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates activity img/indirect-activation.png JAK2 0.612
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination EGFR 0.887
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Glioblastoma Multiforme
+ down-regulates img/direct_inhibition.png relocalization EGFR 0.595
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC3 0.617
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.573
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png glycosylation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation EGFR 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png polyubiquitination EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.923
Publications: 3 Organism: In Vitro, Mus Musculus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ up-regulates img/direct-activation.png binding ERBB2 0.613
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png EGFR 0.574
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png NCK1 0.578
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png binding EGFR 0.899
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Hepatocellular Tumor, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.479
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation EGFR 0.331
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.613
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination EGFR 0.299
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.309
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CBL 0.887
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Glioblastoma Multiforme
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3R1 0.811
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Glioblastoma Multiforme
+ up-regulates img/direct-activation.png binding SHC1 0.913
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, Noonan syndrome
+ up-regulates img/direct-activation.png binding NCK2 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ErbB receptor family 0.671
Publications: 1 Organism: Homo Sapiens
Pathways:Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates activity img/direct_inhibition.png ubiquitination EGFR 0.76
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling
+ up-regulates img/direct-activation.png binding EGFR 0.746
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.754
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding EGFR 0.892
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.76
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation EGFR 0.635
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.77
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
Pathways:EGFR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.404
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation JAK1/STAT1/STAT3 0.631
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC2 0.61
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.643
Publications: 1 Organism: In Vitro
Pathways:EGFR Signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation EGFR 0.293
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding EGFR 0.593
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding EGFR 0.643
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling
+ up-regulates quantity img/indirect-activation.png relocalization EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EGFR 0.643
Publications: 1 Organism: Rattus Norvegicus
Pathways:EGFR Signaling
+ up-regulates quantity by stabilization img/direct-activation.png binding EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EGFR 0.949
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.336
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.329
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png JAK1 0.631
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network
+ up-regulates quantity img/direct-activation.png relocalization EGFR 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.762
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.43
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EGFR 0.735
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/indirect-activation.png EGFR 0.295
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FUS 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PARP1 0.394
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, FLT3-ITD in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT14 0.458
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png destabilization EGFR 0.71
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EGFR 0.77
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.509
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MYC 0.465
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, Hepatocellular Tumor
+ up-regulates activity img/direct-activation.png binding NCK1 0.578
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.376
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png EGFR 0.458
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.479
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.479
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIK3C2B 0.441
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.389
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EGFR 0.401
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.949
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ up-regulates img/direct-activation.png binding EGFR 0.621
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation EGFR 0.395
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png binding SHC1 0.913
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, Noonan syndrome