Summary

Name EGFR
Full Name Epidermal growth factor receptor
Synonyms Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 | ERBB, ERBB1, HER1
Primary ID P00533
Links - -
Type protein
Relations 250
Pathways Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, FLT3-ITD in AML, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), SARS-CoV MAPK PERTURBATION
Inhibitors canertinib; gefitinib; neratinib; lapatinib; WZ4002; sapitinib; CUDC-101; tyrphostin AG 1478; dacomitinib; tyrphostin B42; vandetanib; 9-(1-Methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone; erlotinib hydrochloride; 873837-23-1; XL-647; erlotinib; PD-153035 hydrochloride; afatinib; BMS-599626; AV412; OSI-420; N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-6-quinazolinyl]-2-propenamide; VARLITINIB; pelitinib
Function Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.436
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation SPRED1 0.277
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.379
Publications: 7 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.37
Publications: 2 Organism: , Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ABCA1 0.301
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.376
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.587
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EGFR 0.62
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, FLT3-ITD in AML, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.536
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALM1 0.415
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALM3 0.391
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALM2 0.353
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.605
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.865
Publications: 2 Organism: Chlorocebus Aethiops
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Noonan syndrome
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.2
Publications: 13 Organism: Mus Musculus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, FLT3-ITD in AML, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.751
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.365
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation EGFR 0.508
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.596
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Acute Myeloid Leukemia, EGFR Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.497
Publications: 1 Organism: In Vitro
+ img/unknown.png dephosphorylation EGFR 0.6
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.605
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates img/direct-activation.png phosphorylation EGFR 0.431
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation EGFR 0.497
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation EGFR 0.426
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation MUC1 0.602
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERBB2 0.589
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PLCG1 0.833
Publications: 4 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation ERBB3 0.648
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KCND3 0.2
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation VAV2 0.615
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EZR 0.55
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RGS16 0.428
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLD2 0.537
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation STAM2 0.585
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.577
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GSTP1 0.45
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRB2 0.921
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ up-regulates img/direct-activation.png phosphorylation ANXA1 0.528
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PCNA 0.347
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CCDC50 0.427
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC3 (isoform 2) 0.601
Publications: 4 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CRK 0.73
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CTNND1 0.623
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GAB1 0.749
Publications: 5 Organism: Homo Sapiens
Pathways:EGFR Signaling, Hepatocellular Tumor, Noonan syndrome, PI3K/AKT Signaling
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.749
Publications: 4 Organism: In Vitro, Homo Sapiens
Pathways:EGFR Signaling, Hepatocellular Tumor, Noonan syndrome, PI3K/AKT Signaling
+ up-regulates img/direct-activation.png phosphorylation HGS 0.619
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HGS 0.619
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ASAP3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EZR 0.55
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCAMP1 0.341
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation ERRFI1 0.663
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation SCAMP3 0.41
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation SCAMP3 0.41
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation RASA1 0.637
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ up-regulates quantity img/direct-activation.png phosphorylation TRIP13 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC6 0.454
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NIBAN2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPN1 0.751
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EPB41 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT5B 0.827
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT5B 0.827
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PKIA 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EPS15 0.745
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation LRRK1 0.351
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation EGFR 0.342
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation EGFR 0.3
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.415
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.921
Publications: 3 Organism: Mus Musculus, In Vitro, Homo Sapiens
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Hepatocellular Tumor, Noonan syndrome, Non-small-cell lung cancer (NSCLC), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding ERBB2 0.589
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NCK2 0.409
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EGFR 0.764
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates img/direct-activation.png phosphorylation PIK3C2B 0.452
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens, In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT1 0.727
Publications: 2 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination EGFR 0.699
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ErbB receptor family 0.649
Publications: 1 Organism: Homo Sapiens
Pathways:Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EGFR 0.949
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.522
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png glycosylation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.876
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.499
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.736
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png JAK1 0.61
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT14 0.476
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation JAK1/STAT1/STAT3 0.61
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates activity img/indirect-activation.png MYC 0.487
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, Hepatocellular Tumor
+ down-regulates quantity img/direct_inhibition.png destabilization EGFR 0.699
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png JAK2 0.596
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png relocalization EGFR 0.5
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STAT5A 0.818
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates img/direct-activation.png binding SHC1 0.91
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, Noonan syndrome
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.744
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EGFR 0.895
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling, Hepatocellular Tumor, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/direct-activation.png binding PIK3R1 0.799
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Glioblastoma Multiforme
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity img/indirect-activation.png relocalization EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.761
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.384
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png EGFR 0.301
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding EGFR 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOX2 0.499
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation EGFR 0.616
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.772
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Acute Myeloid Leukemia, COVID-19 Causal Network, FLT3-ITD in AML, Hepatocellular Tumor, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png binding EGFR 0.663
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SHC1 0.91
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, Noonan syndrome
+ up-regulates img/direct-activation.png binding EGFR 0.589
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation EGFR 0.41
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates img/direct-activation.png relocalization CBL 0.88
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Glioblastoma Multiforme
+ up-regulates img/direct-activation.png binding EGFR 0.405
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NCK1 0.594
Publications: 1 Organism: Mus Musculus
Pathways:EGFR Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.663
Publications: 1 Organism: In Vitro
Pathways:EGFR Signaling
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding SHC3 0.601
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.615
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding EGFR 0.745
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png relocalization EGFR 0.575
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png EGFR 0.551
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.76
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EGFR 0.418
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.641
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png binding EGFR 0.949
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, EGFR Signaling, Glioblastoma Multiforme, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), PI3K/AKT Signaling, SARS-CoV MAPK PERTURBATION
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination EGFR 0.308
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation EGFR 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EGFR 0.663
Publications: 1 Organism: Rattus Norvegicus
Pathways:EGFR Signaling
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding EGFR 0.726
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.469
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation EGFR 0.598
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.343
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png EGFR 0.479
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.888
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates activity img/direct_inhibition.png chemical inhibition EGFR 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/indirect-activation.png NCK1 0.594
Publications: 1 Organism: Homo Sapiens
Pathways:EGFR Signaling
+ up-regulates img/direct-activation.png binding SHC2 0.595
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.764
Publications: 2 Organism: Homo Sapiens
Tissue: Skin
Pathways:EGFR Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination EGFR 0.334
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination EGFR 0.88
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Glioblastoma Multiforme
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.616
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination EGFR 0.744
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling