Summary

Name CTDSPL
Full Name CTD small phosphatase-like protein
Synonyms CTDSP-like, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3, NIF-like protein, Nuclear LIM interactor-interacting factor 1, NLI-interacting factor 1, Protein YA22, hYA22, RBSP3, Small C-terminal domain phosphatase 3, SCP3, Small CTD phosphatase 3 | C3orf8, NIF1, NIFL, SCP3, YA22
Primary ID O15194
Links - -
Type protein
Relations 13
Function Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD1
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SMAD3
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation RB1
Publications: 2 Organism: Homo Sapiens