Summary

Name MID1
Full Name E3 ubiquitin-protein ligase Midline-1
Synonyms Midin, Putative transcription factor XPRF, RING finger protein 59, RING finger protein Midline-1, RING-type E3 ubiquitin transferase Midline-1, Tripartite motif-containing protein 18 | FXY, RNF59, TRIM18, XPRF
Primary ID O15344
Links - -
Type protein
Relations 5
Function Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.

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Relations

Regulator Mechanism target score ℹ
+ MID1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PPP2CA 0.452
Publications: 1 Organism: Homo Sapiens
+ MID1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination HMG20B 0.244
Publications: 1 Organism: Homo Sapiens
+ PAK1up-regulates activity img/direct-activation.png phosphorylation MID1 0.2
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination MID1 0.2
Publications: 1 Organism: Homo Sapiens
+ MID1down-regulates quantity img/direct_inhibition.png ubiquitination PTPN1 0.2
Publications: 1 Organism: Homo Sapiens