Summary

Name PPP2CA
Full Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Synonyms PP2A-alpha, Replication protein C, RP-C
Primary ID P67775
Links - -
Type protein
Relations 125
Pathways COVID-19 Causal Network, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES
Function PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png demethylation PPP2CA 0.901
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png methylation PPP2CA 0.906
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation DOCK6 0.2
Publications: 1
+ down-regulates activity img/direct_inhibition.png dephosphorylation SRC 0.446
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SNCA 0.339
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation HDAC7 0.322
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ATM 0.342
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PAK1 0.365
Publications: 3 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png dephosphorylation EIF4E 0.354
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES
+ down-regulates img/direct_inhibition.png dephosphorylation TNNI3 0.385
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png dephosphorylation FOXO 0.412
Publications: 3 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ up-regulates img/direct-activation.png dephosphorylation FOXO3 0.412
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation FCAR 0.328
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png dephosphorylation TFCP2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation HDAC4 0.356
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation CHEK1 0.47
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TP53 0.569
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RACGAP1 0.306
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png dephosphorylation KRT8 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT3 0.719
Publications: 4 Organism: Homo Sapiens, Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.887
Publications: 4 Organism: Homo Sapiens, Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT 0.887
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Pathways:COVID-19 Causal Network, PI3K/AKT Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT2 0.73
Publications: 4 Organism: Mus Musculus, Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAP3K3 0.379
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SP1 0.268
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RPS3 0.396
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation CARD11 0.314
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PRKCD 0.386
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PRKCB (isoform 2) 0.432
Publications: 2 Organism: Rattus Norvegicus
+ img/unknown.png dephosphorylation PPP1R1A 0.429
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png dephosphorylation DDHD1 0.2
Publications: 1 Organism: In Vitro
+ img/unknown.png dephosphorylation DDHD1 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation DCK 0.2
Publications: 1
+ up-regulates activity img/direct-activation.png dephosphorylation BCL2 0.453
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates activity img/direct_inhibition.png dephosphorylation TRPM8 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation TRAF2 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation CILK1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK15 0.294
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STK3 0.678
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STK4 0.379
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK1 0.6
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK1 0.6
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
+ down-regulates img/direct_inhibition.png dephosphorylation MAP3K7 0.334
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK3 0.629
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation MDM2 0.428
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation ELF1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MKNK1 0.486
Publications: 2 Organism: Homo Sapiens
Pathways:PI3K/AKT Signaling
+ up-regulates activity img/direct-activation.png dephosphorylation FOXO3 0.412
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT 0.887
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, PI3K/AKT Signaling
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.887
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PRKCB 0.432
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation TP53 0.569
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation EEF2 0.415
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CHEK2 0.444
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PPP2CA 0.446
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD3 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates img/direct-activation.png dephosphorylation RBL1 0.601
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PPP2CA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CTNNB1 0.436
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPP2CA 0.661
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png dephosphorylation RBL2 0.556
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MEK1/2 0.537
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, PI3K/AKT Signaling
+ up-regulates activity img/direct-activation.png binding PPP2CA 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ form complex img/form-complex.png binding PP2Ca_R1A_Bd 0.901
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation STK3/4 0.731
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation RB1 0.477
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPP2CA 0.855
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PPP2CA 0.2
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding PPP2CA 0.908
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RPS6KB1 0.708
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PPP2CA 0.345
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation Gbeta 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PPP2CA 0.552
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding PP2CA_R1A_R2A 0.932
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PPP2CA 0.313
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAP2K1 0.537
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation ERK1/2 0.631
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, PI3K/AKT Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PPP2CA 0.468
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPP2CA 0.588
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation PPP2CA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation IRF3 0.318
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES
+ up-regulates activity img/direct-activation.png binding PPP2CA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPP2CA 0.957
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation RAF1 0.568
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
Pathways:COVID-19 Causal Network
+ down-regulates img/direct_inhibition.png dephosphorylation MAP2K2 0.465
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding PP2Ca_R1A_Bd 0.826
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RELA 0.468
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PPP2CA 0.94
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation NfKb-p65/p50 0.436
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV STRESS GRANULES