| + |
| up-regulates activity 
binding
|
ADAM12 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282627 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 31888763 |
Aspartate β-hydroxylase (ASPH) drives embryonic cell motility/invasion in pancreatic development/differentiation. We explored if dysregulated ASPH is critically involved in pancreatic cancer pathogenesis.Mechanistically, ASPH activates SRC cascade through direct physical interaction with ADAM12/ADAM15 independent of FAK. The ASPH-SRC axis enables invadopodia construction and initiates MMP-mediated ECM degradation/remodeling as executors for invasiveness. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADAM12 | up-regulates activity
binding
|
SRC |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282629 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 31888763 |
Aspartate β-hydroxylase (ASPH) drives embryonic cell motility/invasion in pancreatic development/differentiation. We explored if dysregulated ASPH is critically involved in pancreatic cancer pathogenesis.Mechanistically, ASPH activates SRC cascade through direct physical interaction with ADAM12/ADAM15 independent of FAK. The ASPH-SRC axis enables invadopodia construction and initiates MMP-mediated ECM degradation/remodeling as executors for invasiveness. ADAM12 or ADAM15 interacts with SH3 domain of SRC [13–15], resulting in activation of the SRC cascade in pancreatic cancer cells (Fig. 2b). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ADAM12 | up-regulates
binding
|
SDC4 |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96931 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12509413 |
The adam12 cysteine-rich domain (radam12-cys) supports cell attachment using syndecan-4 as a primary cell surface receptor that subsequently triggers beta(1) integrin-dependent cell spreading, stress fiber assembly, and focal adhesion formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
4.0
ADAM12
- 
- 