Summary

Name RNF13
Full Name E3 ubiquitin-protein ligase RNF13
Synonyms RING finger protein 13 | RZF
Primary ID O43567
Links - -
Type protein
Relations 1
Function E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:18794910, PubMed:23378536, PubMed:30595371). Involved in apoptosis regulation (PubMed:23378536, PubMed:30595371). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371). Also involved in protein trafficking and localization (PubMed:24387786).

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Relations

Regulator Mechanism target score ℹ
+ RNF13up-regulates activity img/direct-activation.png polyubiquitination SNAPIN 0.543
Publications: 1 Organism: Chlorocebus Aethiops