4.0
Summary
| Name |  ENSAView Modifications |
| Full Name | Alpha-endosulfine |
| Synonyms | ARPP-19e |
| Primary ID | O43768 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. |
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