4.0
Summary
| Name |  CREB3View Modifications |
| Full Name | Cyclic AMP-responsive element-binding protein 3 |
| Synonyms | CREB-3, cAMP-responsive element-binding protein 3, Leucine zipper protein, Luman, Transcription factor LZIP-alpha | LZIP |
| Primary ID | O43889 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613). Associates with chromatin to the HERPUD1 promoter (PubMed:16940180). Also induces transcriptional activation of chemokine receptors (PubMed:18587271, PubMed:17296613). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | down-regulates quantity by destabilization 
phosphorylation
|
CREB3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CREB3 | up-regulates quantity by expression 
transcriptional regulation
|
HERPUD1 | 0.317 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HCFC1 | up-regulates activity 
binding
|
CREB3 | 0.565 |
| Publications: | 1 | Organism: | In Vitro | |