Summary

Name RAD21
Full Name Double-strand-break repair protein rad21 homolog
Synonyms hHR21, Nuclear matrix protein 1, NXP-1, SCC1 homolog | HR21, KIAA0078, NXP1
Primary ID O60216
Links - -
Type protein
Relations 1
Function Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png cleavage RAD21 0.66
Publications: 1 Organism: Homo Sapiens