Relation Results

Summary

Name HCN1
Full Name Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Synonyms Brain cyclic nucleotide-gated channel 1, BCNG-1 | BCNG1
Primary ID O60741
Links - -
Type protein
Relations 1
Function Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacema ...
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Type: Score: Layout: SPV 
0.2RESTHCN1

Relations

Regulator
Mechanism
target
score
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HCN1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268970 Neuron
pmid sentence
Levels of NRSF and its physical binding to the Hcn1 gene were augmented after SE, resulting in repression of HCN1 expression and HCN1-mediated currents (I(h) ), and reduced I(h) -dependent resonance in hippocampal CA1 pyramidal cell dendrites.
Publications: 1
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