| + |
PRKAA2 | up-regulates activity 
phosphorylation
|
PFKFB2 |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250323 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11069105 |
AMPK phosphorylates and activates heart PFK-2 in vitro and in intact cells. activation of PFK-2 was due to the phosphorylation of Ser466 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates activity
phosphorylation
|
PFKFB2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248031 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12853467 |
These findings suggest that PKB-dependent binding of 14-3-3s to phospho-Ser483 of cardiac PFK-2 mediates the stimulation of glycolysis by growth factor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71419 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
|
| pmid |
sentence |
| 10521487 |
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192260 |
Ser483 |
IRRPRNYsVGSRPLK |
Homo sapiens |
|
| pmid |
sentence |
| 23457334 |
Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (pfkfb2) isoenzyme by amino acids. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-103462 |
Ser483 |
IRRPRNYsVGSRPLK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12853467 |
These findings suggest that pkb-dependent binding of 14-3-3s to phospho-ser483 of cardiac pfk-2 mediates the stimulation of glycolysis by growth factor. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Heart |
| Pathways: | AMPK Signaling |
| + |
PRKAA1 | up-regulates activity
phosphorylation
|
PFKFB2 |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260012 |
Ser466 |
PVRMRRNsFTPLSSSN |
Rattus norvegicus |
|
| pmid |
sentence |
| 11069105 |
AMPK phosphorylates and activates heart PFK-2 in vitro and in intact cells. AMPK-mediated PFK-2 activation is likely to be involved in the stimulation of heart glycolysis during ischaemia. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84061 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
|
| pmid |
sentence |
| 11069105 |
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
| Tissue: |
Heart |
| + |
AKT1 | up-regulates activity
phosphorylation
|
PFKFB2 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252584 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
|
| pmid |
sentence |
| 10521487 |
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252555 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12853467 |
These findings suggest that PKB-dependent binding of 14-3-3s to phospho-Ser483 of cardiac PFK-2 mediates the stimulation of glycolysis by growth factor. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252528 |
Ser483 |
IRRPRNYsVGSRPLK |
Homo sapiens |
|
| pmid |
sentence |
| 23457334 |
Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (pfkfb2) isoenzyme by amino acids. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252464 |
Ser483 |
IRRPRNYsVGSRPLK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12853467 |
These findings suggest that pkb-dependent binding of 14-3-3s to phospho-ser483 of cardiac pfk-2 mediates the stimulation of glycolysis by growth factor. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Heart |
| + |
AMPK | up-regulates activity
phosphorylation
|
PFKFB2 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260011 |
Ser466 |
PVRMRRNsFTPLSSSN |
Rattus norvegicus |
|
| pmid |
sentence |
| 11069105 |
AMPK phosphorylates and activates heart PFK-2 in vitro and in intact cells. AMPK-mediated PFK-2 activation is likely to be involved in the stimulation of heart glycolysis during ischaemia. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216623 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
|
| pmid |
sentence |
| 11069105 |
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209947 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
The decreased glycogen synthesis rates upon acute AMPK activation are generally coupled to an increase in the glycolytic flux, thanks to the activation of 6-phosphofructo-2-kinase (PFK-2) through direct phosphorylation on Ser466 [35]. PFK-2 catalyzes the synthesis of fructose 2,6-bisphosphate, a potent stimulator of glycolysis. Therefore, activation of AMPK rapidly mobilizes glucose into ATP-generating processes. |
|
| Publications: |
3 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
| Tissue: |
Heart |
| Pathways: | AMPK Signaling |
| + |
AKT1 |
phosphorylation
|
PFKFB2 |
0.643 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252574 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12853467 |
14-3-3s bind directly to cardiac PFK-2 phosphorylated by PKB. PFK-2 was phosphorylated on both Ser466 and Ser483 by PKB. the precise mechanism of fru-2,6-P2 regulation by 14-3-3s is still puzzling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252575 |
Ser483 |
IRRPRNYsVGSRPLK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12853467 |
14-3-3s bind directly to cardiac PFK-2 phosphorylated by PKB. PFK-2 was phosphorylated on both Ser466 and Ser483 by PKB. the precise mechanism of fru-2,6-P2 regulation by 14-3-3s is still puzzling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RPS6KA3 | up-regulates activity
phosphorylation
|
PFKFB2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23753 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
|
| pmid |
sentence |
| 2846551 |
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-49367 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
|
| pmid |
sentence |
| 9211863 |
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Heart |
| + |
RPS6KB1 | up-regulates activity
phosphorylation
|
PFKFB2 |
0.249 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-49371 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
|
| pmid |
sentence |
| 9211863 |
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-23757 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
|
| pmid |
sentence |
| 2846551 |
Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Heart |
| + |
PRKACA | up-regulates activity
phosphorylation
|
PFKFB2 |
0.454 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250025 |
Ser466 |
PVRMRRNsFTPLSSS |
in vitro |
|
| pmid |
sentence |
| 12853467 |
PFK-2 that was phosphorylated on Ser466, but not Ser483, by PKA did not bind to 14-3-3s‚ |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AKT |
phosphorylation
|
PFKFB2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251484 |
Ser466 |
PVRMRRNsFTPLSSS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12853467 |
14-3-3s bind directly to cardiac PFK-2 phosphorylated by PKB. PFK-2 was phosphorylated on both Ser466 and Ser483 by PKB. the precise mechanism of fru-2,6-P2 regulation by 14-3-3s is still puzzling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251485 |
Ser483 |
IRRPRNYsVGSRPLK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12853467 |
14-3-3s bind directly to cardiac PFK-2 phosphorylated by PKB. PFK-2 was phosphorylated on both Ser466 and Ser483 by PKB. the precise mechanism of fru-2,6-P2 regulation by 14-3-3s is still puzzling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
PRKCA | up-regulates activity
phosphorylation
|
PFKFB2 |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248844 |
Thr475 |
TPLSSSNtIRRPRNY |
in vitro |
|
| pmid |
sentence |
| 1322130 |
The phosphorylation sites for both cAMP-dependent protein kinase and protein kinase C were located in a single peptide whose sequence was Arg-Arg-Asn-Ser-(P)-Phe-Thr-Pro-Leu-Ser-Ser-Ser-Asn-Thr(P)-Ile-Arg-Arg-Pro. The seryl residue nearest the N terminus was the residue specifically phosphorylated by cAMP-dependent protein kinase, whereas the threonine residue nearest the C terminus was phosphorylated by protein kinase C. | Phosphorylation of bovine heart Fru-6-P,B-kinase by either protein kinase C or CAMP-dependent protein kinase results in activation of the enzyme. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PFKFB2 | up-regulates 
|
Glycolysis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209950 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
The decreased glycogen synthesis rates upon acute AMPK activation are generally coupled to an increase in the glycolytic flux, thanks to the activation of 6-phosphofructo-2-kinase (PFK-2) through direct phosphorylation on Ser466 [35]. PFK-2 catalyzes the synthesis of fructose 2,6-bisphosphate, a potent stimulator of glycolysis. Therefore, activation of AMPK rapidly mobilizes glucose into ATP-generating processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
3.0
PFKFB2
- 
- 