Summary

Name AKT1
Full Name RAC-alpha serine/threonine-protein kinase
Synonyms Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha | PKB, RAC
Primary ID P31749
Links - -
Type protein
Relations 361
Pathways Myostatin, IGF and Myogenesis, P38 Signaling and Myogenesis, Glioblastoma Multiforme, Parkinson disease, Adipogenesis, Eosinophil: IL5, FAP: PDGFR alpha, Satellite: IGF1
Inhibitors Perifosine; PF-04691502; 937174-76-0; 1032350-13-2
Function AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png deacetylation AKT1
Publications: 1 Organism: Mus Musculus
Tissue: Heart
+ down-regulates quantity by destabilization img/direct_inhibition.png desumoylation AKT1 0.08
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png sumoylation AKT1 0.13
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, binding CDKN1B 0.24
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation YBX1 0.16
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.12
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H3F3A 0.06
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PALLD 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation FANCA 0.15
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PEA15 0.15
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOS3 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.34
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RANBP3 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation YAP1 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.16
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.19
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Glioblastoma Multiforme
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.11
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation MST1R 0.08
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CCDC88A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ZYX 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DNMT1 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MXD1 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOR1 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1A
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GAB2 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MDM2
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png phosphorylation MDM2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EP300 0.15
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation BAX 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BAX 0.19
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation HMOX1 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KHSRP 0.13
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP9 0.19
Publications: 3 Organism: In Vitro, Homo Sapiens
Pathways:Parkinson disease
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.19
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO
Publications: 7 Organism: Mus Musculus, Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation FOXO4 0.12
Publications: 5 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO
Publications: 10 Organism: Homo Sapiens, In Vitro, Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO4
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation HNRNPA1 0.20
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EZH2 0.13
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.27
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HTRA2 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:Parkinson disease
+ down-regulates img/direct_inhibition.png phosphorylation AR
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation AR
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation TERT 0.12
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MTOR 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme, Parkinson disease, Satellite: IGF1
+ up-regulates img/direct-activation.png phosphorylation TP53RK 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO
Publications: 4 Organism: , Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO3
Publications: 3
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.34
Publications: 4 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation, relocalization FOXO1 0.33
Publications: 5 Organism: In Vitro, Homo Sapiens, Mus Musculus
Pathways:Adipogenesis, IGF and Myogenesis, Myostatin
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.21
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Myotube
Pathways:Adipogenesis
+ img/unknown.png phosphorylation ARFIP2 0.11
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CCT2 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation METTL1 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CFLAR 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CHEK1 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1C 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PHF20 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PDE3B 0.11
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation PDE3B 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SH3RF1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NCF1 0.06
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PIKFYVE 0.13
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation GATA1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BMI1 0.09
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation CLK2 0.07
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ADRB2 0.10
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NR4A1 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VCP 0.15
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BRAF 0.19
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ up-regulates img/direct-activation.png phosphorylation MDM4 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TTC3 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation VIM 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K8 0.09
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K8 0.09
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GATA2 0.10
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ img/unknown.png phosphorylation HTT 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EIF4B 0.12
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ACLY 0.15
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation PDCD4 0.16
Publications: 3 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates img/direct-activation.png phosphorylation PFKFB3 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.08
Publications: 4 Organism: Homo Sapiens
Tissue: Heart
+ img/unknown.png phosphorylation PFKFB2 0.08
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1
Publications: 6 Organism: Homo Sapiens, Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.73
Publications: 3 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme, Parkinson disease, Satellite: IGF1
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1
Publications: 4 Organism: Homo Sapiens, Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.04
Publications: 2 Organism: Homo Sapiens
Pathways:Parkinson disease
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.34
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1
Publications: 5 Organism: Homo Sapiens
Tissue: Brain
Pathways:Adipogenesis, Glioblastoma Multiforme, IGF and Myogenesis, Myostatin
+ up-regulates activity img/direct-activation.png phosphorylation AKT1
Publications: 1
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.19
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPN1 0.12
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation CARHSP1 0.12
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.22
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation ACAP1 0.02
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPARGC1A 0.12
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ img/unknown.png phosphorylation YWHAZ 0.27
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SH2B2 0.01
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation SH2B2 0.01
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation COPS6 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NUAK1 0.06
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation FAM129A 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation, binding NOS3 0.18
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ILF3 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K11 0.11
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAC1 0.42
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DLC1 0.08
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation ATXN1 0.07
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP2K4 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation HSPB1 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation XIAP 0.19
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary Cancer Cell
Pathways:Parkinson disease
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2L11 0.10
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation, unknown GSK3B 0.59
Publications: 3 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Adipogenesis, IGF and Myogenesis, Satellite: IGF1
+ down-regulates img/direct_inhibition.png phosphorylation ZFP36L1 0.07
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC2 0.26
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation RARA 0.09
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DAB2IP 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AGAP2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRAK1 0.13
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STK3 0.13
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STK4 0.15
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation RNF11 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDCA7 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PLN 0.02
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation ALYREF 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHUK 0.24
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation POU5F1 0.03
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation S1PR1 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MTOR 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme, Parkinson disease, Satellite: IGF1
+ down-regulates activity img/direct_inhibition.png phosphorylation AKT1S1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.68
Publications: 2 Organism: Homo Sapiens,
Pathways:Adipogenesis, Glioblastoma Multiforme, IGF and Myogenesis, Myostatin
+ up-regulates activity img/direct-activation.png phosphorylation AKT1
Publications: 1
Pathways:IGF and Myogenesis
+ down-regulates activity img/direct_inhibition.png dephosphorylation AKT1
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation AKT1
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation PPP1CA 0.15
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ img/unknown.png phosphorylation LTB4R2 0.01
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK2 0.11
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation AKT1
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SKI 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SRPK2 0.12
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation WNK1 0.19
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TBC1D4 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB3
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TAL1 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1
Publications: 1 Organism: Mus Musculus
Tissue: Prostate Adenocarcinoma Cell
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.10
Publications: 3 Organism: Homo Sapiens
Tissue: Prostate Gland
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.28
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown AKT1 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown AKT1 0.16
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png phosphorylation AKT1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT1
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization AKT1 0.20
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown AKT1 0.69
Publications: 2 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.12
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown AKT1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png relocalization AKT1
Publications: 3 Organism: Homo Sapiens
Tissue: Prostate Gland Cancer Cell, Breast Cancer Cell, Skeletal Muscle
Pathways:Adipogenesis, Glioblastoma Multiforme, IGF and Myogenesis, Myostatin
+ up-regulates img/indirect-activation.png unknown AKT1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AKT1 0.12
Publications: 1 Organism: Homo Sapiens
Tissue: Liver
+ up-regulates activity img/indirect-activation.png unknown AKT1
Publications: 4 Organism: Homo Sapiens
Tissue: Breast Cancer Cell, Colonic Cancer Cell
Pathways:Satellite: IGF1
+ down-regulates activity img/direct_inhibition.png phosphorylation PRKAA1 0.24
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation TBC1D4 0.15
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC1/TSC2
Publications: 2 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation FOXO6 0.01
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown SLC2A4 0.23
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC2A1 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PHB2 0.13
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation mTORC1
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Muscle, Skeletal Muscle, Myotube
Pathways:Glioblastoma Multiforme
+ up-regulates img/direct-activation.png phosphorylation SP7 0.06
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HK1 0.12
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLX5 0.08
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown PRKACA 0.19
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown FAS 0.15
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png unknown AKT1 0.04
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AKT1
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding AKT1
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding SMAD3 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Myostatin
+ up-regulates img/indirect-activation.png phosphorylation AKT1
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/indirect-activation.png unknown AKT1 0.06
Publications: 1 Organism: Homo Sapiens
Pathways:Eosinophil: IL5
+ up-regulates img/indirect-activation.png unknown Proliferation
Publications: 2 Organism: Homo Sapiens
Pathways:Eosinophil: IL5, FAP: PDGFR alpha, Glioblastoma Multiforme
+ up-regulates img/indirect-activation.png unknown Fibrosis
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown AKT1 0.10
Publications: 1 Organism: Homo Sapiens
Pathways:FAP: PDGFR alpha
+ up-regulates activity img/indirect-activation.png unknown AKT1
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT1
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination AKT1
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding AKT1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Satellite: IGF1
+ up-regulates img/direct-activation.png phosphorylation MTOR 0.73
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Glioblastoma Multiforme, Parkinson disease, Satellite: IGF1
+ down-regulates img/indirect_inhibition.png unknown AKT1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding AKT1 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation IKK-complex
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png unknown AKT1
Publications: 4 Organism: Homo Sapiens
Tissue: Colonic Cancer Cell, Breast Cancer Cell
Pathways:Glioblastoma Multiforme, IGF and Myogenesis, Myostatin
+ up-regulates img/indirect-activation.png unknown AKT1 0.07
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/indirect_inhibition.png unknown AKT1 0.16
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png chemical activation AKT1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT1 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding AKT1 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation P300/PCAF
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1B 0.24
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png transcriptional regulation CDKN1B
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown AKT1 0.06
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/indirect-activation.png unknown AKT1 0.24
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis, Myostatin, P38 Signaling and Myogenesis, Satellite: IGF1
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO1
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, IGF and Myogenesis, Myostatin
+ up-regulates activity img/indirect-activation.png unknown MEF2C 0.09
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates img/indirect-activation.png unknown MEF2D 0.16
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation FOXO1 0.33
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, IGF and Myogenesis, Myostatin
+ up-regulates img/indirect-activation.png unknown AKT1 0.20
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation AKT1 0.03
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation AKT1 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png cleavage AKT1 0.21
Publications: 1 Organism: In Vitro
Pathways:Parkinson disease
+ down-regulates img/indirect_inhibition.png unknown AKT1 0.07
Publications: 1 Organism: Homo Sapiens