Summary

Name CDC45
Full Name Cell division control protein 45 homolog
Synonyms PORC-PI-1 | CDC45L, CDC45L2
Primary ID O75419
Links - -
Type protein
Relations 2
Function Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. {ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding CDC45 0.519
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding MCM 0.953
Publications: 1 Organism: Homo Sapiens