3.0
Summary
| Name |  ERLIN1
|
| Full Name | Erlin-1 |
| Synonyms | Endoplasmic reticulum lipid raft-associated protein 1, Protein KE04, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1, SPFH domain-containing protein 1 | C10orf69, KE04, KEO4, SPFH1 |
| Primary ID | O75477 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618). |
binding