Summary

Name NEURL1
Full Name E3 ubiquitin-protein ligase NEURL1
Synonyms Neuralized-like protein 1A, h-neu, h-neuralized 1, RING finger protein 67, RING-type E3 ubiquitin transferase NEURL1 | NEURL, NEURL1A, RNF67
Primary ID O76050
Links - -
Type protein
Relations 2
Function Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination NEURL1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PDE9A 0.2
Publications: 1 Organism: Homo Sapiens