| + |
PRKCD | down-regulates activity 
phosphorylation
|
BEST1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260880 |
Ser358 |
SAQFRRAsFMGSTFN |
Homo sapiens |
|
| pmid |
sentence |
| 19635817 |
We have identified a PKC phosphorylation site (S358) located in the C terminal region of hBest1 critical for channel rundown. Phosphorylation of this site by PKC activators and PP2A inhibitors reduces channel rundown. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOX9 | up-regulates quantity by expression 
transcriptional regulation
|
BEST1 |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255187 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20530484 |
BEST1 promoter activity was increased by SOX9 overexpression and decreased by siRNA-mediated SOX9 knockdown. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CRX | up-regulates quantity by expression
transcriptional regulation
|
BEST1 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253815 |
|
|
in vitro |
|
| pmid |
sentence |
| 18849347 |
Three OTX family proteins - OTX1, OTX2 and CRX - bound to both Sites 1 and 2 in vitro, and all of them increased BEST1 promoter activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
OTX2 | up-regulates quantity by expression
transcriptional regulation
|
BEST1 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255186 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20530484 |
BEST1 promoter activity was increased by SOX9 overexpression and decreased by siRNA-mediated SOX9 knockdown. SOX9 physically interacted with MITF and OTX2 and orchestrated synergistic activation of the BEST1 promoter with the paired SOX site playing essential roles. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254888 |
|
|
in vitro |
|
| pmid |
sentence |
| 18849347 |
Three OTX family proteins - OTX1, OTX2 and CRX - bound to both Sites 1 and 2 in vitro, and all of them increased BEST1 promoter activity. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, In Vitro |
| + |
OTX1 | up-regulates quantity by expression
transcriptional regulation
|
BEST1 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254887 |
|
|
in vitro |
|
| pmid |
sentence |
| 18849347 |
Three OTX family proteins - OTX1, OTX2 and CRX - bound to both Sites 1 and 2 in vitro, and all of them increased BEST1 promoter activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MITF | up-regulates quantity by expression
transcriptional regulation
|
BEST1 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255185 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20530484 |
BEST1 promoter activity was increased by SOX9 overexpression and decreased by siRNA-mediated SOX9 knockdown. SOX9 physically interacted with MITF and OTX2 and orchestrated synergistic activation of the BEST1 promoter with the paired SOX site playing essential roles. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254586 |
|
|
Homo sapiens |
D-407 Cell |
| pmid |
sentence |
| 14982938 |
These studies define the VMD2 promoter region sufficient to drive RPE-specific expression in the eye, identify positive regulatory regions in vitro, and suggest that MITF as well as other E-box binding factors may act as positive regulators of VMD2 expression. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
3.0
BEST1
- 
- 