Summary

Name DDHD2
Full Name Phospholipase DDHD2
Synonyms DDHD domain-containing protein 2, KIAA0725p, SAM, WWE and DDHD domain-containing protein 1 | KIAA0725, SAMWD1
Primary ID O94830
Links - -
Type protein
Relations 3
Function Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane.

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Relations

Regulator Mechanism target score ℹ
+ DDHD2up-regulates quantity img/direct-activation.png chemical modification long-chain fatty acid anion 0.8
Publications: 1 Organism: Homo Sapiens
+ DDHD2down-regulates quantity img/direct_inhibition.png chemical modification phosphatidic acid 0.8
Publications: 1 Organism: Homo Sapiens
+ DDHD2up-regulates quantity img/direct-activation.png chemical modification 1-acyl-sn-glycerol 3-phosphate 0.8
Publications: 1 Organism: Homo Sapiens