Summary

Name SEC24D
Full Name Protein transport protein Sec24D
Synonyms SEC24-related protein D | KIAA0755
Primary ID O94855
Links - -
Type protein
Relations 2
Function Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding COPII vesicle 0.678
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding SEC24D 0.703
Publications: 1