3.0
Summary
| Name |  ELP1View Modifications |
| Full Name | Elongator complex protein 1 |
| Synonyms | ELP1, IkappaB kinase complex-associated protein, IKK complex-associated protein, p150 | ELP1, IKAP |
| Primary ID | O95163 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MTOR | up-regulates activity 
phosphorylation
|
ELP1 | 0.2 |
| Publications: | 1 | |||
| + | mTORC2 | up-regulates activity
phosphorylation
|
ELP1 | 0.2 |
| Publications: | 1 | |||
| + | ELP1 | up-regulates 
|
MAPK8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ELP1 | form complex 
binding
|
Elongator complex | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |