Summary

Name LRAT
Full Name Lecithin retinol acyltransferase
Synonyms Phosphatidylcholine--retinol O-acyltransferase |
Primary ID O95237
Links - -
Type protein
Relations 2
Function Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png chemical modification all-trans-retinyl ester 0.8
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png chemical modification retinol 0.8
Publications: 1 Organism: Mus Musculus