4.0
Summary
| Name |  RAPGEF3View Modifications |
| Full Name | Rap guanine nucleotide exchange factor 3 |
| Synonyms | Exchange factor directly activated by cAMP 1, Exchange protein directly activated by cAMP 1, EPAC 1, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP, cAMP-regulated guanine nucleotide exchange factor I, cAMP-GEFI | CGEF1, EPAC, EPAC1 |
| Primary ID | O95398 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GRK2 | down-regulates activity 
phosphorylation
|
RAPGEF3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAPGEF3 | up-regulates activity 
guanine nucleotide exchange factor
|
RAP1A | 0.712 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | RAPGEF3 | up-regulates activity
guanine nucleotide exchange factor
|
RAP1B | 0.72 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |