Relation Results

Summary

Name CLDN7
Full Name Claudin-7
Synonyms CLDN-7 | CEPTRL2, CPETRL2
Primary ID O95471
Links - -
Type protein
Relations 4
Function Plays a major role in tight junction-specific obliteration of the intercellular space.

Viewer

Type: Score: Layout: SPV 
0.4130.3990.20.2SNAI1CLDN7TACSTD2CTBP1HDAC1

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ SNAI1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CLDN7 0.413
Identifier Residue Sequence Organism Cell Line
SIGNOR-254104 Homo sapiens MDA-MB-468 Cell
pmid sentence
We propose that CtBP1 is recruited by SNAI1P at the CLDN7 gene promoter indirectly through another yet to be identified protein. Based on our observations, we propose a model for SNAI1P-mediated down regulation of human CLDN7 gene expression by chromatin remodeling
Publications: 1 Organism: Homo Sapiens
+ TACSTD2up-regulates quantity img/direct-activation.png binding CLDN7 0.399
Identifier Residue Sequence Organism Cell Line
SIGNOR-273822 Homo sapiens HCT-116 Cell
pmid sentence
In summary, our findings provide evidence that Trop-2 is phosphorylated at Ser-322 by PKCα/δ and that this phosphorylation enhances cell motility and decreases claudin-7 localization to cellular borders.
Publications: 1 Organism: Homo Sapiens
+ CTBP1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CLDN7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254105 Homo sapiens MDA-MB-468 Cell
pmid sentence
ChIP assays revealed that SNAI1P is recruited on the CLDN7 gene promoter along with the co-repressor CtBP1 and the effector HDAC1.
Publications: 1 Organism: Homo Sapiens
+ HDAC1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CLDN7 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254106 Homo sapiens MDA-MB-468 Cell
pmid sentence
ChIP assays revealed that SNAI1P is recruited on the CLDN7 gene promoter along with the co-repressor CtBP1 and the effector HDAC1.|These data further suggest that HDAC1 is involved in the SNAI1P-mediated repression of the human CLDN7 gene promoter.
Publications: 1 Organism: Homo Sapiens
a simple tooltip