Summary

Name YEATS4
Full Name YEATS domain-containing protein 4
Synonyms Glioma-amplified sequence 41, Gas41, NuMA-binding protein 1, NuBI-1, NuBI1 | GAS41
Primary ID O95619
Links - -
Type protein
Relations 1
Function Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12963728, PubMed:14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed:29437725, PubMed:30071723, PubMed:29900004). Also able to recognize and bind crotonylated histone H3 (PubMed:30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed:29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions

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Relations

Regulator Mechanism target score ℹ
+ YEATS4form complex img/form-complex.png binding NuA4 complex 0.759
Publications: 1 Organism: Homo Sapiens