Summary

Name FADS2
Full Name Acyl-CoA 6-desaturase
Synonyms Acyl-CoA 6-desaturase, Delta(6) fatty acid desaturase, D6D, Delta(6) desaturase, Delta-6 desaturase |
Primary ID O95864
Links - -
Type protein
Relations 2
Pathways Fatty Acid Synthesis
Function Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:12713571). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have potent antibacterial activity (PubMed:12713571). It can also desaturate (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png chemical modification long-chain fatty acyl-CoA(4-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates quantity img/direct-activation.png chemical modification arachidonoyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis