| + |
REST | down-regulates quantity by repression 
transcriptional regulation
|
PENK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255074 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21832040 |
HIPPI could bind to the promoter of REST and increased its expression in neuronal as well as non-neuronal cells. Such activation of REST down-regulated expression of REST target genes, such as brain-derived neurotrophic factor (BDNF) or proenkephalin (PENK). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF2BPL | down-regulates quantity by repression 
transcriptional regulation
|
PENK |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267155 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 17627301 |
EAP1 encoded a nuclear protein expressed in neurons involved in the inhibitory and facilitatory control of reproduction. EAP1 transactivated genes required for reproductive function, such as GNRH1, and repressed inhibitory genes, such as preproenkephalin. It contained a RING finger domain of the C3HC4 subclass required for this dual transcriptional activity.These results suggest that EAP1 is a transcriptional regulator that, acting within the neuroendocrine brain, contributes to controlling female reproductive function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PENK
- 
- 