| + |
KLKB1 | up-regulates activity 
cleavage
|
F12 |
0.584 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263520 |
Arg353 |
EQPPSLTrNGPLSCG |
Homo sapiens |
|
| pmid |
sentence |
| 28966616 |
FXIIa converts PK to the active protease PKa, which reciprocally activates more FXII|In addition, PKa can initiate a further proteolysis of FXIIa into a ~30 kDa light chain fragment, termed β-FXIIa. The cleavage takes place at the peptide bond Arg353–Val354 and consequently, the active site released from the heavy chain and thus from surfaces. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Plasma |
| + |
KLKB1 | up-regulates activity
cleavage
|
KNG1 |
0.773 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263547 |
Arg381 |
GMISLMKrPPGFSPF |
Homo sapiens |
|
| pmid |
sentence |
| 28966616 |
Bradykinin is a nonapeptide composed of the sequence Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg and functions as an inflammatory mediator. BK is the product of the kallikrein–kinin system following activation of FXII. FXIIa leads to proteolysis of PK, and the resulting PKa cleaves HK to generate BK (Figure 1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263548 |
Arg389 |
PPGFSPFrSSRIGEI |
Homo sapiens |
|
| pmid |
sentence |
| 28966616 |
Bradykinin is a nonapeptide composed of the sequence Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg and functions as an inflammatory mediator. BK is the product of the kallikrein–kinin system following activation of FXII. FXIIa leads to proteolysis of PK, and the resulting PKa cleaves HK to generate BK (Figure 1). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Plasma |
| + |
F12 | up-regulates activity
cleavage
|
KLKB1 |
0.584 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263518 |
Arg390 |
CTTKTSTrIVGGTNS |
Homo sapiens |
|
| pmid |
sentence |
| 28966616 |
FXIIa activates two serine proteinases, factor XI (FXI) and plasma prekallikrein (PK) that drive the coagulation and kallikrein–kinin systems, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Plasma |
| + |
KLKB1 | up-regulates activity
cleavage
|
HGF |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256513 |
Arg424 |
KNMEDLHrHIFWEPD |
in vitro |
|
| pmid |
sentence |
| 12372819 |
the ability of plasma kallikrein and FXIa to activate pro-HGF in vitro raises the possibility that mediators of inflammation and blood coagulation may also regulate processes that involve the HGF/c-Met pathway, such as tissue repair and angiogenesis.Unlike other known activators, both FXIa and kallikrein processed pro-HGF by cleavage at two sites. Using N-terminal sequencing they were identified as the normal cleavage site Arg(494)-Val(495) and the novel site Arg(424)-His(425) located in the K4 domain of the alpha-chain. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256512 |
Arg494 |
CAKTKQLrVVNGIPT |
in vitro |
|
| pmid |
sentence |
| 12372819 |
the ability of plasma kallikrein and FXIa to activate pro-HGF in vitro raises the possibility that mediators of inflammation and blood coagulation may also regulate processes that involve the HGF/c-Met pathway, such as tissue repair and angiogenesis.Unlike other known activators, both FXIa and kallikrein processed pro-HGF by cleavage at two sites. Using N-terminal sequencing they were identified as the normal cleavage site Arg(494)-Val(495) and the novel site Arg(424)-His(425) located in the K4 domain of the alpha-chain. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
KLKB1 | up-regulates activity
cleavage
|
MST1 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256511 |
Arg483 |
DQRRSKLrVVGGHPG |
in vitro |
|
| pmid |
sentence |
| 10068459 |
Proteolytic cleavage of pro-MSP at a single site yields active MSP, a disulfide-linked alphabeta-chain heterodimer. human kallikrein cleaved only at Arg483–Val484, the cleavage site for formation of a- and b-chains. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
KLKB1
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