| + |
Pyridostigmine | down-regulates activity 
chemical inhibition
|
BCHE |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257880 |
|
|
in vitro |
|
| pmid |
sentence |
| 20627738 |
The compounds 3-[(dimethylamino)carboxyl]oxy]-N,N,N-trimethylammonium methyl sulfate, better known as neostigmine methyl sulfate (3),1 and 3-[(dimethylcarbamoyl)oxy]-1-methylpyridinium bromide, pyridostigmine bromide (4)2 (Figure 1) are well known peripheral cholinesterase inhibitors |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
BCHE | down-regulates quantity
chemical modification
|
acetylcholine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253982 |
|
|
|
|
| pmid |
sentence |
| 15841900 |
The other subgroup, butyrylcholinesterase (BuChE) (or acyl- choline acyl-hydrolase, EC 3.1.1.8) also known as plasma, serum, benzoyl, false, butyryl, nonspecific, or type II ChE. BuChE exists in plasma and has more than eleven isoenzy- me variants. BuChE is also present in liver, smooth muscle, intestines, pancreas, heart and white matter of brain |It hydrolyzes butyrylcholine 4 times more rapidly than acetylcholine. |
|
| Publications: |
1 |
| + |
HIPK2 | down-regulates quantity
phosphorylation
|
BCHE |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279190 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25210797 |
As shown in XREF_FIG, HIPK2 overexpression strongly reduced Myc-Che-1 levels, whereas it produced little effect on Che-1 T144A expression.|Notably, we found that HIPK2 phosphorylates a specific residue of Che-1, which is required for its interaction with Pin1 and for its degradation through the proteasome pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BCHE
- 
- 