3.0
Summary
| Name |  GPIView Modifications |
| Full Name | Glucose-6-phosphate isomerase |
| Synonyms | GPI, Autocrine motility factor, AMF, Neuroleukin, NLK, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI, Sperm antigen 36, SA-36 |
| Primary ID | P06744 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Pathways | Glycolysis and Gluconeogenesis |
| Function | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | down-regulates activity 
phosphorylation
|
GPI | 0.338 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM25 | down-regulates quantity by destabilization
ubiquitination
|
GPI | 0.254 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GPI | up-regulates quantity 
chemical modification
|
β-D-fructose 6-phosphate | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | GPI | up-regulates
binding
|
AMFR | 0.551 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GPI | down-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | AMFR | down-regulates quantity by destabilization
polyubiquitination
|
GPI | 0.551 |
| Publications: | 1 | Organism: | Homo Sapiens | |