| + |
CSNK2A1 | down-regulates activity 
phosphorylation
|
GPI |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250869 |
Ser185 |
GPRVWYVsNIDGTHI |
Homo sapiens |
Fibrosarcoma Cell |
| pmid |
sentence |
| 15637053 |
It is known that human PGI/AMF is phosphorylated at Ser(185) by protein kinase CK2 (CK2) | These results demonstrate that phosphorylation affects the allosteric kinetic properties of the enzyme, resulting in a less active form of PGI, whereas non-phosphorylated protein species retain cytokine activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMFR | down-regulates quantity by destabilization
polyubiquitination
|
GPI |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272177 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24810856 |
Gp78 is a ubiquitin ligase that plays a vital role in endoplasmic reticulum (ER)-associated degradation (ERAD). Here we report that autocrine motility factor (AMF), also known as phosphoglucose isomerase (PGI), is a novel substrate of gp78. We show that polyubiquitylation of AMF requires cooperative interaction between gp78 and the ubiquitin ligase TRIM25 (tripartite motif-containing protein 25). While TRIM25 mediates the initial round of ubiquitylation, gp78 catalyzes polyubiquitylation of AMF. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM25 | down-regulates quantity by destabilization
ubiquitination
|
GPI |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272178 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24810856 |
Gp78 is a ubiquitin ligase that plays a vital role in endoplasmic reticulum (ER)-associated degradation (ERAD). Here we report that autocrine motility factor (AMF), also known as phosphoglucose isomerase (PGI), is a novel substrate of gp78. We show that polyubiquitylation of AMF requires cooperative interaction between gp78 and the ubiquitin ligase TRIM25 (tripartite motif-containing protein 25). While TRIM25 mediates the initial round of ubiquitylation, gp78 catalyzes polyubiquitylation of AMF. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPI | down-regulates quantity
chemical modification
|
alpha-D-glucose 6-phosphate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266461 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Glucose 6-phosphate isomerase (GPI) catalyzes the interconversion of G6P into fructose-6-phosphate (F6P) in the second step of the Embden-Meyerhof pathway (Figure 1). As a result of this reversible reaction, products of the hexose-monophosphate shunt can be recycled to G6P. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PPM1D | down-regulates activity
dephosphorylation
|
GPI |
0.241 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277155 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28185954 |
The WIP1 mediated inhibition of NLK activity markedly decreased the phosphorylation of lymphoid enhancer binding factor 1 (LEF1), enhancing its interaction with beta-catenin.|Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPI | up-regulates 
binding
|
AMFR |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97270 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12527360 |
Pgi is a housekeeping gene encoding phosphoglucose isomerase (pgi) a glycolytic enzyme that also functions as a cytokine (autocrine motility factor (amf)/neuroleukin/maturation factor) upon secretion from the cell and binding to its 78 kda seven-transmembrane domain receptor (gp78/amf-r) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPI | up-regulates quantity
chemical modification
|
β-D-fructose 6-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266462 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16051738 |
Glucose 6-phosphate isomerase (GPI) catalyzes the interconversion of G6P into fructose-6-phosphate (F6P) in the second step of the Embden-Meyerhof pathway (Figure 1). As a result of this reversible reaction, products of the hexose-monophosphate shunt can be recycled to G6P. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
3.0
GPI
- 
- 