3.0
Summary
| Name |  PFN1View Modifications |
| Full Name | Profilin-1 |
| Synonyms | Epididymis tissue protein Li 184a, Profilin I |
| Primary ID | P07737 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PPP1CA | up-regulates 
dephosphorylation
|
PFN1 | 0.248 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ROCK1 | down-regulates 
phosphorylation
|
PFN1 | 0.276 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PFN1 | up-regulates activity
|
CDH4 | 0.342 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RHOA | up-regulates activity
|
PFN1 | 0.55 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PFN1 | up-regulates 
|
Actin_cytoskeleton_reorganization | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |