Summary

Name RHOA
Full Name Transforming protein RhoA
Synonyms Rho cDNA clone 12, h12 | ARH12, ARHA, RHO12
Primary ID P61586
Links - -
Type protein
Relations 92
Pathways Satellite: WNT, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
Function Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers (PubMed:8910519, PubMed:9121475, PubMed:31570889). Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (PubMed:16236794, PubMed:12900402). Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion (PubMed:20974804, PubMed:23940119). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (PubMed:20937854). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (PubMed:31888991). May be an activator of PLCE1 (PubMed:16103226). In neurons, involved in the inhibiton of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOA 0.495
Publications: 1 Organism: Mus Musculus
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation MSN 0.635
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RDX 0.489
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EZR 0.75
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOA 0.655
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RHOA 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RHOA 0.608
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding PLD1 0.684
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.597
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.659
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.526
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.744
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.888
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination RHOA 0.661
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RHOA 0.2
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RHOA 0.408
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RHOA 0.552
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.611
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.418
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png DIAPH1 0.776
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.743
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.531
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png F-actin_assembly 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.551
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.734
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RHOA 0.612
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.535
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RHOA 0.826
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.543
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.898
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.502
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.76
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.799
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.401
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.654
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.857
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.901
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.826
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.617
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.625
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RHOA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png RHOA 0.624
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ROCK1 0.804
Publications: 2 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.739
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.739
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.63
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RHOA 0.815
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.531
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RHOA 0.536
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization FHL2 0.357
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.824
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.691
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RHOA 0.595
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.56
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding RHOA 0.274
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.542
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.507
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RHOA 0.901
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.475
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.563
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.609
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.768
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png PFN1 0.548
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.528
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.822
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding RHOA 0.357
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.549
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.65
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RHOA 0.2
Publications: 1
+ up-regulates activity img/direct-activation.png binding RHOA 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor RHOA 0.824
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.525
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAPK8 0.819
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.489
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.76
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.82
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png binding RHOA 0.387
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.478
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.697
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RHOA 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.44
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.599
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PKN1 0.846
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PKN2 0.824
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.702
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png gtpase-activating protein RHOA 0.618
Publications: 1 Organism: Homo Sapiens