Summary

Name LAMB1
Full Name Laminin subunit beta-1
Synonyms Laminin B1 chain, Laminin-1 subunit beta, Laminin-10 subunit beta, Laminin-12 subunit beta, Laminin-2 subunit beta, Laminin-6 subunit beta, Laminin-8 subunit beta
Primary ID P07942
Links - -
Type protein
Relations 4
Function Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding Laminin-1 0.613
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation LAMB1 0.269
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Laminin-10 0.708
Publications: 1
+ form complex img/form-complex.png binding Laminin-8 0.6
Publications: 1