Summary

Name WNT2
Full Name Protein Wnt-2
Synonyms Int-1-like protein 1, Int-1-related protein, IRP | INT1L1, IRP
Primary ID P09544
Links - -
Type protein
Relations 3
Function Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding LRP5 0.61
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.661
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png WNT2 0.312
Publications: 1 Organism: Mus Musculus