Summary

Name H2AZ1
Full Name Histone H2A.Z
Synonyms H2A/z | H2AZ
Primary ID P0C0S5
Links - -
Type protein
Relations 4
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png monoubiquitination H2AZ1 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png H2AZ1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ form complex img/form-complex.png binding Nucleosome_H2A.Z.1 variant 0.2
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png translation regulation H2AZ1 0.2
Publications: 1 Organism: Homo Sapiens