+ |
ATAT1 | up-regulates quantity by stabilization
acetylation
|
TUBA3C |
0.244 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272244 |
Lys40 |
DGQMPSDkTIGGGDD |
in vitro |
|
pmid |
sentence |
29703898 |
Alpha-Tubulin acetyltransferase (alphaTAT1) is the major α-tubulin lysine-40 (K40) acetyltransferase in mammals, nematodes, and protozoa, and its activity plays a conserved role in several microtubule-based processes.|The tubulin subunits of microtubules are acetylated, and lysine-40 (K40) of the alpha-tubulin subunit has been identified as an important conserved site of microtubule acetylation (6–8). This modification is considered a hallmark of stable, long-lived microtubules |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
Elongator complex | up-regulates activity
acetylation
|
TUBA3C |
0.254 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269716 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
19185337 |
Elongator Subunits Interact with the Microtubules and Are Required for Proper Acetylation of α-Tubulin. α-Tubulin Acetylation Promotes Radial Migration and Branching of Cortical Projection Neurons |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TUBA3C | up-regulates
|
Neuron_migration |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269724 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
19185337 |
We show here that Elongator regulates corticogenesis because an acute disruption of its activity in dorsal progenitors results in radial migration delays and defective terminal branching of projection neurons that come with a reduction in α-tubulin acetylation. Importantly, this complex interacts with the microtubule cytoskeleton, where Elp3 may directly acetylate α-tubulin, a posttranslational modification known to regulate the intracellular trafficking that is critical for cell shape remodeling during migration and terminal branching. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |