| + |
CDK9 | down-regulates activity
phosphorylation
|
H1-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279691 |
Ser187 |
KPKKAPKsPAKAKAV |
Homo sapiens |
|
| pmid |
sentence |
| 28539972 |
These data provide further evidence that CDK9 phosphorylates H1.4-S187, and that the level of pS187-H1.4 at genes is directly related to the extent of co-enrichment of CDK9.|that enrichment of pS187-H1.4 at genes is positively related to their transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AURKB | up-regulates quantity by stabilization
phosphorylation
|
H1-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262658 |
Ser27 |
VKKKARKsAGAAKRK |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21511733 |
we showed previously that phosphorylation of S27 in human histone H1.4 (H1.4S27-P), prevents binding of heterochromatin protein 1 (HP1) family members (officially known as chromobox protein homologs) to the neighboring dimethylated K26. Here, we present the first functional characterization of H1.4S27-P in vivo and in vitro. We show that H1.4S27 phosphorylation is cell-cycle-regulated and its levels peak on metaphase chromosomes. We identify further Aurora B as the kinase phosphorylating H1.4S27. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |