3.0
Summary
| Name |  EPB41View Modifications |
| Full Name | Protein 4.1 |
| Synonyms | P4.1, 4.1R, Band 4.1, EPB4.1 | E41P |
| Primary ID | P11171 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | EGFR | down-regulates 
phosphorylation
|
EPB41 | 0.409 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EPB41 | form complex 
binding
|
4.1 complex | 0.416 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EPB41 | up-regulates activity 
relocalization
|
NUMA1 | 0.549 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EPB41 | up-regulates activity
relocalization
|
DLG1 | 0.485 |
| Publications: | 1 | Organism: | Canis Lupus Familiaris | |